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胰腺肿瘤的基因组图谱。

Genomic landscapes of pancreatic neoplasia.

作者信息

Wood Laura D, Hruban Ralph H

机构信息

The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

J Pathol Transl Med. 2015 Jan;49(1):13-22. doi: 10.4132/jptm.2014.12.26. Epub 2015 Jan 15.

Abstract

Pancreatic cancer is a deadly disease with a dismal prognosis. However, recent advances in sequencing and bioinformatic technology have led to the systematic characterization of the genomes of all major tumor types in the pancreas. This characterization has revealed the unique genomic landscape of each tumor type. This knowledge will pave the way for improved diagnostic and therapeutic approaches to pancreatic tumors that take advantage of the genetic alterations in these neoplasms.

摘要

胰腺癌是一种预后极差的致命疾病。然而,测序和生物信息学技术的最新进展已促使对胰腺中所有主要肿瘤类型的基因组进行系统表征。这种表征揭示了每种肿瘤类型独特的基因组格局。这些知识将为利用这些肿瘤中的基因改变来改进胰腺癌的诊断和治疗方法铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d67a/4357405/6d11316bcb1a/jptm-49-1-13f1.jpg

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