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肿瘤浸润性CD8 +淋巴细胞对黏膜皮肤黑色素瘤临床结局的影响

Tumor-Infiltrating CD8+ Lymphocytes Effect on Clinical Outcome of Muco-Cutaneous Melanoma.

作者信息

Rahbar Mahtab, Naraghi Zahra Safaei, Mardanpour Marjan, Mardanpour Nyousha

机构信息

Department of surgical Pathology, Kermanshah Medical University, Kermanshah, Iran.

Department of Dermathopatology, Tehran Medical University, Kermanshah, Iran.

出版信息

Indian J Dermatol. 2015 Mar-Apr;60(2):212. doi: 10.4103/0019-5154.152571.

DOI:10.4103/0019-5154.152571
PMID:25814732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4372936/
Abstract

BACKGROUND

Recent data have changed our views of prognostic factors in cutaneous melanoma, while some newer methods have yielded better prognostic information. Tumor-infiltrating lymphocytes are believed to represent the immune reaction/response to melanoma cells which is often found in melanocytic cancer.

AIM AND OBJECTIVE

We carried out an analysis, aiming to establish pooled estimates for clinical outcomes based on the presence of CD8+ T cell in melanocytic cancer.

MATERIALS AND METHODS

We have included 42 patients with primary cutaneous melanocytic cancer without preoperative treatments in our study. We next analyzed the proliferative activity of CD8+ T cells that infiltrated in tumor cell nests. The intratumoral and adjacent to invasive margin of tumor CD+ T-cell infiltration were analyzed which could also reflect antitumor immunity.

RESULTS

The total number of CD8+ cells especially adjacent to invasive margin of tumor was positively correlated with anatomical tumor thickness (P < .001) and not correlated with patient's age and sex. The stage of tumor which is related to vascular-neural invasion, regional lymph nodes involvement and tumor thickness shows positive correlation with CD8+ infiltration in tumor (P < .004, P < .005, P < .001), respectively. Acral melanoma shows more CD8 lymphocytes infiltration and also recurrence rate of tumor (P < .005).

CONCLUSION

We believe that CD8+ T-cell infiltration in primary cutaneous melanocytic cancer represents the immune reaction/response to melanoma which could be an important new therapy for melanoma although more research is needed on this treatment modality.

摘要

背景

近期数据改变了我们对皮肤黑色素瘤预后因素的看法，同时一些新方法提供了更好的预后信息。肿瘤浸润淋巴细胞被认为代表了对黑色素瘤细胞的免疫反应，这种反应在黑素细胞癌中经常可见。

目的

我们进行了一项分析，旨在基于黑素细胞癌中CD8 + T细胞的存在情况建立临床结局的汇总估计。

材料与方法

我们的研究纳入了42例未经术前治疗的原发性皮肤黑素细胞癌患者。接下来，我们分析了浸润在肿瘤细胞巢中的CD8 + T细胞的增殖活性。分析了肿瘤内和肿瘤浸润边缘附近的CD + T细胞浸润情况，这也可以反映抗肿瘤免疫力。

结果

CD8 +细胞总数，尤其是肿瘤浸润边缘附近的细胞总数，与肿瘤解剖厚度呈正相关（P <.001），与患者年龄和性别无关。与血管神经侵犯、区域淋巴结受累和肿瘤厚度相关的肿瘤分期，分别与肿瘤中CD8 +浸润呈正相关（P <.004，P <.005，P <.001）。肢端黑色素瘤显示更多的CD8淋巴细胞浸润以及更高的肿瘤复发率（P <.005）。

结论

我们认为原发性皮肤黑素细胞癌中的CD8 + T细胞浸润代表了对黑色素瘤的免疫反应，这可能是黑色素瘤的一种重要新疗法，尽管对此治疗方式还需要更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d0/4372936/fdcd1bbce6c3/IJD-60-212d-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d0/4372936/ee2d2f7a5632/IJD-60-212d-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d0/4372936/fdcd1bbce6c3/IJD-60-212d-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d0/4372936/ee2d2f7a5632/IJD-60-212d-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51d0/4372936/fdcd1bbce6c3/IJD-60-212d-g004.jpg

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