干细胞临床应用的基质。
Substrates for clinical applicability of stem cells.
机构信息
Sanjar Enam, Sha Jin, Department of Biomedical Engineering, Thomas J Watson School of Engineering and Applied Sciences, State University of New York in Binghamton, Binghamton, NY 13902, United States.
出版信息
World J Stem Cells. 2015 Mar 26;7(2):243-52. doi: 10.4252/wjsc.v7.i2.243.
Abstract
The capability of human pluripotent stem cells (hPSCs) to differentiate into a variety of cells in the human body holds great promise for regenerative medicine. Many substrates exist on which hPSCs can be self-renewed, maintained and expanded to further the goal of clinical application of stem cells. In this review, we highlight numerous extracellular matrix proteins, peptide and polymer based substrates, scaffolds and hydrogels that have been pioneered. We discuss their benefits and shortcomings and offer future directions as well as emphasize commercially available synthetic peptides as a type of substrate that can bring the benefits of regenerative medicine to clinical settings.
摘要
人多能干细胞（hPSCs）分化为人体多种细胞的能力为再生医学带来了巨大的希望。许多基质存在于这些基质上，hPSCs 可以在这些基质上自我更新、维持和扩增，以进一步实现干细胞的临床应用目标。在这篇综述中，我们重点介绍了许多已经开创的细胞外基质蛋白、肽和聚合物基质、支架和水凝胶。我们讨论了它们的优点和缺点，并提供了未来的发展方向，同时强调了商业可用的合成肽作为一种可以将再生医学的益处带给临床环境的基质类型。
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