Tedaldi Ellen M, Minniti Nancy L, Fischer Tracy
Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Department of Physical Medicine and Rehabilitation, Temple University Hospital, Philadelphia, PA 19140, USA.
Biomed Res Int. 2015;2015:641913. doi: 10.1155/2015/641913. Epub 2015 Mar 1.
The prevalence of HIV (human immunodeficiency virus) associated neurocognitive disorders (HAND) will undoubtedly increase with the improved longevity of HIV-infected persons. HIV infection, itself, as well as multiple physiologic and psychosocial factors can contribute to cognitive impairment and neurologic complications. These comorbidities confound the diagnosis, assessment, and interventions for neurocognitive disorders. In this review, we discuss the role of several key comorbid factors that may contribute significantly to the development and progression of HIV-related neurocognitive impairment, as well as the current status of diagnostic strategies aimed at identifying HIV-infected individuals with impaired cognition and future research priorities and challenges.
随着感染人类免疫缺陷病毒（HIV）者寿命的延长，与HIV相关的神经认知障碍（HAND）的患病率无疑将会上升。HIV感染本身以及多种生理和心理社会因素均可导致认知障碍和神经并发症。这些合并症使得神经认知障碍的诊断、评估及干预变得复杂。在本综述中，我们讨论了几个关键合并因素在HIV相关神经认知障碍发生和发展过程中可能发挥的重要作用，以及旨在识别认知受损的HIV感染者的诊断策略现状，还有未来的研究重点和挑战。
