Zhou Tingting, Chen Xuannan, Lai Yu
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Acupunture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Immunol. 2025 Feb 3;16:1478187. doi: 10.3389/fimmu.2025.1478187. eCollection 2025.
In the combination antiretroviral therapy era, HIV-associated neurocognitive disorder (HAND) is still widespread among HIV-infected individuals. However, there is no effective treatment for HAND, and the exact pathogenic mechanism of HAND remains unknown. This paper aims to provide a reference for further exploration in the field of HAND research.
We used CiteSpace software to collect 3057 articles related to HAND in the Web of Science Core Collection for comprehensive analysis. Betweenness centrality, count, and burst values were used as indicators in the visualization analysis, aiming to predict future new directions and cutting-edge trends.
The last decade has been the peak period of HAND research, with the most prominent contributions by authors, countries, and institutions being Grant, Igor (135), the USA (2211), and the University of California System (758), respectively. The most frequently cited article is "HIV-associated neurocognitive disorders persist in the area of potent antiretroviral therapy: CHARTER Study." The hotspots in this field are "neurocognitive impairment," "central nervous system," "cerebrospinal fluid," "HIV-1 tat," "SIV," "inflammation," "infection," and "pathogenesis." The current research direction of HAND is focused on exploring the pathogenic mechanism underlying HIV-associated neurocognitive impairment and potential therapeutic targets.
This study provides a bibliometric visualization of HAND-related literature to gain insight into the development and frontiers of this research field. The study also provides scholars with detailed references and identifies future research directions to better promote the development of this field of research.
在联合抗逆转录病毒治疗时代，人类免疫缺陷病毒相关神经认知障碍（HAND）在艾滋病毒感染者中仍然普遍存在。然而，目前尚无针对HAND的有效治疗方法，其确切致病机制仍不清楚。本文旨在为HAND研究领域的进一步探索提供参考。
我们使用CiteSpace软件收集了Web of Science核心合集中3057篇与HAND相关的文章进行综合分析。在可视化分析中，使用中介中心性、频次和突现值作为指标，旨在预测未来的新方向和前沿趋势。
过去十年是HAND研究的高峰期，作者、国家和机构的最突出贡献分别是Grant, Igor（135篇）、美国（2211篇）和加利福尼亚大学系统（758篇）。被引用次数最多的文章是“高效抗逆转录病毒治疗时代HIV相关神经认知障碍持续存在：CHARTER研究”。该领域的热点包括“神经认知障碍”“中枢神经系统”“脑脊液”“HIV-1反式激活蛋白”“猴免疫缺陷病毒”“炎症”“感染”和“发病机制”。目前HAND的研究方向集中在探索HIV相关神经认知障碍的致病机制和潜在治疗靶点。
本研究提供了HAND相关文献的文献计量可视化分析，以洞察该研究领域的发展和前沿。该研究还为学者提供了详细的参考文献，并确定了未来的研究方向，以更好地推动该研究领域的发展。
