Liu Yisi, Chen Xi, Huang Shuqiong, Tian Liqiao, Lu Yuan'an, Mei Yan, Ren Meng, Li Na, Liu Li, Xiang Hao
School of Public Health, Wuhan University, Wuhan 430071, Hubei Province, China.
Global Health Institute, Wuhan University, Wuhan 430071, Hubei Province, China.
Int J Environ Res Public Health. 2015 Mar 25;12(4):3506-16. doi: 10.3390/ijerph120403506.
We examined the associations of daily mean concentrations of ambient air pollutants (particulate matter (PM10), sulfur dioxide (SO2), nitric oxide (NO2)) and daily cardiovascular diseases (CVD) mortality in Wuhan, China using a case-crossover design to analyze four years of data (2006-2009) collected from the Hubei Provincial Center for Disease Control and Prevention and the Wuhan Environmental Protection Bureau. From 2006 to 2009, daily average concentrations of PM10, SO2 and NO2 were 115.60 µg/m3, 53.21 µg/m3 and 53.08 µg/m3, respectively. After adjusting for temperature and relative humidity, a 10 µg/m3 increase in SO2 and NO2 over a 24-h period was associated with CVD mortality relative risk (R.R.) of 1.010 (95% CI: 1.000, 1.020) for SO2 and 1.019 (95% CI: 1.005, 1.033) for NO2, but there was no significant association between increases in PM10 and mortality. Subgroup analysis on by gender showed a significant association of 1.026 (95% CI: 1.007, 1.045) between NO2 and CVD among males, while no significant statistical effect was shown among females. Subgroup analysis by age showed that for those older than 65 years, every 10 µg/m3 increase in NO2 was associated with a 1.6% (95% CI: 0.1%, 3.1%) increase in CVD mortality. Subgroup analysis on different types of CVD showed that every 10 µg/m3 increase in PM10 and SO2 were significantly associated with an approximately 1.012 (95% CI: 1.002, 1.022) and 1.021 (95% CI: 1.002, 1.040) increase, respectively, in ischemic heart disease (ICH) mortality. In conclusion, exposure to NO2 is significantly associated with CVD mortality. Larger, multi-center studies in Chinese cities are being currently conducted to validate these findings.
我们采用病例交叉设计，分析了从湖北省疾病预防控制中心和武汉市环境保护局收集的四年（2006 - 2009年）数据，以研究中国武汉市环境空气污染物（颗粒物（PM10）、二氧化硫（SO2）、二氧化氮（NO2））的日平均浓度与每日心血管疾病（CVD）死亡率之间的关联。2006年至2009年期间，PM10、SO2和NO2的日平均浓度分别为115.60μg/m³、53.21μg/m³和53.08μg/m³。在调整温度和相对湿度后，24小时内SO2和NO2每增加10μg/m³，与CVD死亡率相对风险（R.R.）分别为1.010（95%置信区间：1.000, 1.020）的SO2和1.019（95%置信区间：1.005, 1.033）的NO2相关，但PM10增加与死亡率之间无显著关联。按性别进行的亚组分析显示，男性中NO2与CVD之间存在显著关联，相对风险为1.026（95%置信区间：1.007, 1.045），而女性中未显示出显著的统计学效应。按年龄进行的亚组分析表明，对于65岁以上的人群，NO2每增加10μg/m³，与CVD死亡率增加1.6%（95%置信区间：0.1%, 3.1%）相关。对不同类型CVD的亚组分析显示，PM10和SO2每增加10μg/m³，分别与缺血性心脏病（ICH）死亡率显著增加约1.（95%置信区间：1.002, 1.022）和1.021（95%置信区间：1.002, 1.040）相关。总之，暴露于NO2与CVD死亡率显著相关。目前正在中国城市开展更大规模的多中心研究以验证这些发现。 （注：原文中“1.（95%置信区间：1.002, 1.022）”疑似有误，已按原样翻译）
