Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel.
Center for Epigenetics and Metabolism, Department of Biological Chemistry, U904 INSERM, University of California, Irvine, Irvine, CA 92697, USA.
Cell. 2015 Mar 26;161(1):84-92. doi: 10.1016/j.cell.2015.03.015.
The circadian clock, a highly specialized, hierarchical network of biological pacemakers, directs and maintains proper rhythms in endocrine and metabolic pathways required for organism homeostasis. The clock adapts to environmental changes, specifically daily light-dark cycles, as well as rhythmic food intake. Nutritional challenges reprogram the clock, while time-specific food intake has been shown to have profound consequences on physiology. Importantly, a critical role in the clock-nutrition interplay appears to be played by the microbiota. The circadian clock appears to operate as a critical interface between nutrition and homeostasis, calling for more attention on the beneficial effects of chrono-nutrition.
生物钟是一个高度专业化的、分层的生物节律器网络，指导和维持着内分 泌和代谢途径中维持机体稳态所必需的节律。生物钟适应环境变化，特别是日 光-黑暗周期，以及有节奏的食物摄入。营养挑战会重新编程生物钟，而特定时 间的食物摄入对生理有深远的影响。重要的是，微生物组似乎在时钟-营养互作 中起着关键作用。生物钟似乎是营养与稳态之间的关键界面，这就要求人们更加 关注chrono-nutrition 的有益作用。
