Thaiss Christoph A, Zeevi David, Levy Maayan, Segal Eran, Elinav Eran
a Department of Immunology ; Weizmann Institute of Science ; Rehovot , Israel.
Gut Microbes. 2015;6(2):137-42. doi: 10.1080/19490976.2015.1016690.
Life on Earth is dictated by circadian changes in the environment, caused by the planet's rotation around its own axis. All forms of life have evolved clock systems to adapt their physiology to the daily variations in geophysical parameters. The intestinal microbiome serves as a signaling hub in the communication between the host and its environment. We recently discovered that the microbiota undergoes diurnal oscillations in composition and function, and that these oscillations are required for metabolic homeostasis of the host. Here, we highlight these findings from the perspectives of microbial system stability and meta-organismal metabolic health. We also discuss the contribution of nutrition and biotic interventions on diurnal processes of the microbiota and their potential involvement in diseases commonly associated with circadian disruption.
地球上的生命受地球自转引起的环境昼夜变化所支配。所有生命形式都进化出了生物钟系统，以使自身生理机能适应地球物理参数的每日变化。肠道微生物群是宿主与其环境之间通讯的信号枢纽。我们最近发现，微生物群在组成和功能上会发生昼夜振荡，并且这些振荡是宿主代谢稳态所必需的。在此，我们从微生物系统稳定性和超生物体代谢健康的角度突出这些发现。我们还讨论了营养和生物干预对微生物群昼夜过程的作用及其在通常与昼夜节律紊乱相关疾病中的潜在参与情况。
