微生物群落的一天：肠道微生物群及其宿主的昼夜节律
A day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host.
作者信息
Thaiss Christoph A, Zeevi David, Levy Maayan, Segal Eran, Elinav Eran
机构信息
a Department of Immunology ; Weizmann Institute of Science ; Rehovot , Israel.
出版信息
Gut Microbes. 2015;6(2):137-42. doi: 10.1080/19490976.2015.1016690.
Abstract
Life on Earth is dictated by circadian changes in the environment, caused by the planet's rotation around its own axis. All forms of life have evolved clock systems to adapt their physiology to the daily variations in geophysical parameters. The intestinal microbiome serves as a signaling hub in the communication between the host and its environment. We recently discovered that the microbiota undergoes diurnal oscillations in composition and function, and that these oscillations are required for metabolic homeostasis of the host. Here, we highlight these findings from the perspectives of microbial system stability and meta-organismal metabolic health. We also discuss the contribution of nutrition and biotic interventions on diurnal processes of the microbiota and their potential involvement in diseases commonly associated with circadian disruption.
摘要
地球上的生命受地球自转引起的环境昼夜变化所支配。所有生命形式都进化出了生物钟系统，以使自身生理机能适应地球物理参数的每日变化。肠道微生物群是宿主与其环境之间通讯的信号枢纽。我们最近发现，微生物群在组成和功能上会发生昼夜振荡，并且这些振荡是宿主代谢稳态所必需的。在此，我们从微生物系统稳定性和超生物体代谢健康的角度突出这些发现。我们还讨论了营养和生物干预对微生物群昼夜过程的作用及其在通常与昼夜节律紊乱相关疾病中的潜在参与情况。
相似文献
1
A day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host.微生物群落的一天：肠道微生物群及其宿主的昼夜节律
Gut Microbes. 2015;6(2):137-42. doi: 10.1080/19490976.2015.1016690.
2
The Oscillating Gut Microbiome and Its Effects on Host Circadian Biology.肠道微生物群的摆动及其对宿主昼夜节律生物学的影响。
Annu Rev Nutr. 2022 Aug 22;42:145-164. doi: 10.1146/annurev-nutr-062320-111321. Epub 2022 May 16.
3
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations.微生物组昼夜节律性程序控制宿主转录组的震荡。
Cell. 2016 Dec 1;167(6):1495-1510.e12. doi: 10.1016/j.cell.2016.11.003.
4
The relationship between host circadian rhythms and intestinal microbiota: A new cue to improve health by tea polyphenols.宿主昼夜节律与肠道微生物群的关系：茶多芬通过改善健康的新线索。
Crit Rev Food Sci Nutr. 2021;61(1):139-148. doi: 10.1080/10408398.2020.1719473. Epub 2020 Jan 30.
5
Microbiome diurnal rhythmicity and its impact on host physiology and disease risk.微生物组的昼夜节律及其对宿主生理和疾病风险的影响。
EMBO Rep. 2019 Apr;20(4). doi: 10.15252/embr.201847129. Epub 2019 Mar 15.
6
Circadian Rhythm and the Gut Microbiome.昼夜节律与肠道微生物群
Int Rev Neurobiol. 2016;131:193-205. doi: 10.1016/bs.irn.2016.07.002. Epub 2016 Sep 6.
7
Complex interactions of circadian rhythms, eating behaviors, and the gastrointestinal microbiota and their potential impact on health.昼夜节律、饮食行为和胃肠道微生物群之间的复杂相互作用及其对健康的潜在影响。
Nutr Rev. 2017 Sep 1;75(9):673-682. doi: 10.1093/nutrit/nux036.
8
Message in a biota: gut microbes signal to the circadian clock.生物群中的信息：肠道微生物向生物钟发出信号。
Cell Host Microbe. 2015 May 13;17(5):541-3. doi: 10.1016/j.chom.2015.04.013.
9
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.跨界控制微生物群落昼夜节律波动促进代谢稳态。
Cell. 2014 Oct 23;159(3):514-29. doi: 10.1016/j.cell.2014.09.048. Epub 2014 Oct 16.
10
The Microbiome as a Circadian Coordinator of Metabolism.肠道菌群作为代谢的生物钟协调者。
Endocrinology. 2020 Jun 1;161(6). doi: 10.1210/endocr/bqaa059.
引用本文的文献
1
Gut Microbial Postbiotics as Potential Therapeutics for Lymphoma: Proteomics Insights of the Synergistic Effects of Nisin and Urolithin B Against Human Lymphoma Cells.肠道微生物源后生元作为淋巴瘤的潜在治疗方法：乳酸链球菌素和尿石素B对人淋巴瘤细胞协同作用的蛋白质组学见解
Int J Mol Sci. 2025 Jul 16;26(14):6829. doi: 10.3390/ijms26146829.
2
Circadian Disruption and Sleep Disorders in Astronauts: A Review of Multi-Disciplinary Interventions for Long-Duration Space Missions.宇航员的昼夜节律紊乱与睡眠障碍：长期太空任务的多学科干预综述
Int J Mol Sci. 2025 May 28;26(11):5179. doi: 10.3390/ijms26115179.
3
Circadian Rhythm Dysregulation in Inflammatory Bowel Disease: Mechanisms and Chronotherapeutic Approaches.炎症性肠病中的昼夜节律失调：机制与时辰治疗方法
Int J Mol Sci. 2025 Apr 15;26(8):3724. doi: 10.3390/ijms26083724.
4
Effects of the sampling time on the vaginal microbiota in healthy pregnant women: a prospective observational study.采样时间对健康孕妇阴道微生物群的影响：一项前瞻性观察性研究。
AJOG Glob Rep. 2025 Feb 16;5(1):100460. doi: 10.1016/j.xagr.2025.100460. eCollection 2025 Feb.
5
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation.系统理解人类健康和疾病中微生物组的框架：从基础原理到临床转化。
Signal Transduct Target Ther. 2024 Sep 23;9(1):237. doi: 10.1038/s41392-024-01946-6.
6
Time of sample collection is critical for the replicability of microbiome analyses.样本采集时间对于微生物组分析的可重复性至关重要。
Nat Metab. 2024 Jul;6(7):1282-1293. doi: 10.1038/s42255-024-01064-1. Epub 2024 Jul 1.
7
Chemical interplay between gut microbiota and epigenetics: Implications in circadian biology.肠道微生物群与表观遗传学之间的化学相互作用：对昼夜节律生物学的影响。
Cell Chem Biol. 2025 Jan 16;32(1):61-82. doi: 10.1016/j.chembiol.2024.04.016. Epub 2024 May 21.
8
Metabolites: a converging node of host and microbe to explain meta-organism.代谢物：宿主与微生物的汇聚节点，用于解释元生物体。
Front Microbiol. 2024 Mar 5;15:1337368. doi: 10.3389/fmicb.2024.1337368. eCollection 2024.
9
Chronodisruption and Gut Microbiota: Triggering Glycemic Imbalance in People with Type 2 Diabetes.昼夜节律紊乱与肠道微生物群：引发2型糖尿病患者的血糖失衡
Nutrients. 2024 Feb 23;16(5):616. doi: 10.3390/nu16050616.
10
Gut metabolic changes during pregnancy reveal the importance of gastrointestinal region in sample collection.孕期肠道代谢变化揭示了胃肠道区域在样本采集时的重要性。
Metabolomics. 2024 Mar 9;20(2):40. doi: 10.1007/s11306-024-02099-x.
本文引用的文献
1
Diet and feeding pattern affect the diurnal dynamics of the gut microbiome.饮食和喂养模式会影响肠道微生物群的昼夜动态变化。
Cell Metab. 2014 Dec 2;20(6):1006-17. doi: 10.1016/j.cmet.2014.11.008.
2
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.限时进食是一种针对多种营养挑战的预防和治疗性干预措施。
Cell Metab. 2014 Dec 2;20(6):991-1005. doi: 10.1016/j.cmet.2014.11.001.
3
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.跨界控制微生物群落昼夜节律波动促进代谢稳态。
Cell. 2014 Oct 23;159(3):514-29. doi: 10.1016/j.cell.2014.09.048. Epub 2014 Oct 16.
4
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.人工甜味剂通过改变肠道微生物群诱导葡萄糖不耐受。
Nature. 2014 Oct 9;514(7521):181-6. doi: 10.1038/nature13793. Epub 2014 Sep 17.
5
Circadian disorganization alters intestinal microbiota.昼夜节律紊乱会改变肠道微生物群。
PLoS One. 2014 May 21;9(5):e97500. doi: 10.1371/journal.pone.0097500. eCollection 2014.
6
Microbes, microbiota, and colon cancer.微生物、微生物组和结肠癌。
Cell Host Microbe. 2014 Mar 12;15(3):317-28. doi: 10.1016/j.chom.2014.02.007.
7
Reprogramming of the circadian clock by nutritional challenge.营养挑战对生物钟的重编程。
Cell. 2013 Dec 19;155(7):1464-78. doi: 10.1016/j.cell.2013.11.034.
8
Diet rapidly and reproducibly alters the human gut microbiome.饮食可快速且可重复地改变人类肠道微生物组。
Nature. 2014 Jan 23;505(7484):559-63. doi: 10.1038/nature12820. Epub 2013 Dec 11.
9
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.微生物组调节与神经发育障碍相关的行为和生理异常。
Cell. 2013 Dec 19;155(7):1451-63. doi: 10.1016/j.cell.2013.11.024. Epub 2013 Dec 5.
10
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.炎症相关癌症：肿瘤、免疫细胞和微生物之间的串扰。
Nat Rev Cancer. 2013 Nov;13(11):759-71. doi: 10.1038/nrc3611.
Zotero 插件