Laboratory of Nutrition and Hygiene, Shaanxi Normal University, Xi'an 710062, China.
Laboratory of Nutrition and Hygiene, Shaanxi Normal University, Xi'an 710062, China.
Carbohydr Polym. 2015 May 20;122:189-96. doi: 10.1016/j.carbpol.2014.12.082. Epub 2015 Jan 14.
To detect the treatment effect of the fruits of Ziziphus Jujube in Chronic Fatigue Syndrome (CFS). Jujube polysaccharide conjugates (JPC) were isolated from the fruits of Z. Jujube. General physicochemical properties of JPC were analyzed. A four-week rats CFS model was established and JPC were orally administrated, the behavior experiments were conducted after CFS. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA) in serum were elevated and T lymphocyte proliferation, CD4(+)/CD8(+) ratio and natural killer (NK) cells activity were analyzed. JPC markedly improved behaviors of CFS rats, also decreased MDA levels in serum, and elevated T lymphocyte proliferation, CD4(+)/CD8(+) ratio and natural killer (NK) cells activities. This suggests that JPC can improve the immune system and antioxidant activity of CFS rats and might be regarded as a biological response modifier.
为了检测大枣（Ziziphus Jujube）果实对慢性疲劳综合征（CFS）的治疗效果。从大枣果实中分离出大枣多糖缀合物（JPC）。分析 JPC 的一般理化性质。建立为期四周的大鼠 CFS 模型，并口服 JPC，在 CFS 后进行行为实验。结果表明，JPC 能明显改善 CFS 大鼠的行为，降低血清 MDA 水平，提高 T 淋巴细胞增殖、CD4+/CD8+比值和自然杀伤（NK）细胞活性。这表明 JPC 可以改善 CFS 大鼠的免疫系统和抗氧化活性，可作为生物反应调节剂。
