Zhu Di, Zhu Yu, Tan Hao, Ding Rui, Dai Qiangqiang, Du Xiaoming, Liu Yulin, Yue Rensong
Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China.
Chengdu Sport University Chengdu China.
Food Sci Nutr. 2024 May 22;12(8):5312-5328. doi: 10.1002/fsn3.4234. eCollection 2024 Aug.
This study aimed to evaluate the effects of jujube ( Mill.) fruit extracts on oxidative stress levels in rodent models. Animal studies meeting the inclusion criteria were retrieved from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and VIP Periodical Service Platform. The Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) risk-of-bias tool was used to evaluate the risk of bias in the included studies. A meta-analysis was performed based on the guidelines provided in the Cochrane Handbook for Systematic Reviews of Interventions (CHSRI) by using Stata 17.0 software. Nineteen studies were included in the meta-analysis. Jujube fruit extracts significantly decreased the level of malonaldehyde (MDA) and increased the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Meanwhile, there was no significant improvement in the catalase (CAT) levels. In addition, there was considerable heterogeneity in the results of the meta-analysis. The results of the subgroup analysis indicated that the animal model, type of extracts, and source of target parameters may have contributed to the heterogeneity. Jujube fruit extracts are healthy and effective antioxidant dietary supplements that may be an effective adjunctive therapy for diseases in which oxidative stress is a major pathological factor. However, the overall methodological quality of the included studies was low, and additional research is warranted.
本研究旨在评估枣（Mill.）果实提取物对啮齿动物模型氧化应激水平的影响。从PubMed、科学网、Embase、中国知网（CNKI）、万方数据知识服务平台和维普期刊服务平台检索符合纳入标准的动物研究。采用实验动物系统评价中心（SYRCLE）偏倚风险工具评估纳入研究的偏倚风险。根据《Cochrane系统评价干预措施手册》（CHSRI）提供的指南，使用Stata 17.0软件进行荟萃分析。荟萃分析纳入了19项研究。枣果实提取物显著降低了丙二醛（MDA）水平，提高了超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）水平。同时，过氧化氢酶（CAT）水平没有显著改善。此外，荟萃分析结果存在相当大的异质性。亚组分析结果表明，动物模型、提取物类型和目标参数来源可能导致了异质性。枣果实提取物是健康有效的抗氧化膳食补充剂，可能是氧化应激为主要病理因素的疾病的有效辅助治疗方法。然而，纳入研究的总体方法学质量较低，需要进一步研究。
