Scott Elizabeth M, Hermens Daniel F, White Django, Naismith Sharon L, GeHue Jeanne, Whitwell Bradley G, Glozier Nick, Hickie Ian B
Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia.
BMJ Open. 2015 Mar 27;5(3):e007066. doi: 10.1136/bmjopen-2014-007066.
To determine the body mass, cardiovascular and metabolic characteristics of young people presenting for mental healthcare.
Cross-sectional assessments of body mass, cardiovascular and metabolic risk factors.
Two primary-care based sites in Sydney, Australia for young people in the early stages of mental disorders.
A clinical sample of young people (12-30 years) with mental health problems.
Daily smoking rates, body mass index (BMI), blood glucose and lipids, blood pressure (BP) and pulse rate.
Of 1005 young people who had their BMI determined (62% female; 19.0±3.5 years), three quarters (739/1005) also had BP recordings and one-third (298/1005) had blood sampling. Clinically, 775 were assigned to one of three diagnostic categories (anxious-depression: n=541; mania-fatigue, n=104; developmental-psychotic n=130). The profile of BMI categories approximated that of the comparable segments of the Australian population. Older age, lower levels of social functioning and higher systolic BP were all associated with high BMI. In a subset (n=129), current use of any psychotropic medication was associated (p<0.05) with increased BMI. Almost one-third of cases were current daily smokers (compared to population rate of 11%). Males had a higher proportion of raised glucose and high-density lipoprotein (HDL) compared to females (9.3% and 34.1% vs 2.1% and 5.9%, respectively). Overall, there was no relationship between BMI and fasting glucose but significant relationships with triglycerides and HDL were noted. Furthermore, there were no significant relationships between diagnostic subgroup and metabolic profiles.
Daily smoking rates are increased among young people presenting for mental healthcare. However, these young people do not demonstrate adverse cardiometabolic profiles. The high levels of smoking, and association of BMI with adverse social circumstances, suggest that risk factors for chronic disease are already present and likely to be compounded by medication and social disadvantage.
确定寻求心理保健的年轻人的体重、心血管和代谢特征。
对体重、心血管和代谢风险因素进行横断面评估。
澳大利亚悉尼的两个基于初级保健的场所，针对处于精神障碍早期阶段的年轻人。
有心理健康问题的年轻人（12 - 30岁）的临床样本。
每日吸烟率、体重指数（BMI）、血糖和血脂、血压（BP）及脉搏率。
在1005名测定了BMI的年轻人中（62%为女性；年龄19.0±3.5岁），四分之三（739/1005）也有血压记录，三分之一（298/1005）进行了血液采样。临床上，775人被归入三个诊断类别之一（焦虑 - 抑郁：n = 541；躁狂 - 疲劳，n = 104；发育 - 精神病性，n = 130）。BMI类别分布与澳大利亚人口的可比部分相似。年龄较大、社会功能水平较低和收缩压较高均与高BMI相关。在一个亚组（n = 129）中，当前使用任何精神药物与BMI升高相关（p<0.05）。近三分之一的病例为当前每日吸烟者（相比总体人口率为11%）。男性血糖升高和高密度脂蛋白（HDL）升高的比例高于女性（分别为9.3%和34.1%，相比女性为2.1%和5.9%）。总体而言，BMI与空腹血糖之间无关联，但与甘油三酯和HDL有显著关联。此外，诊断亚组与代谢特征之间无显著关联。
寻求心理保健的年轻人中每日吸烟率增加。然而，这些年轻人未表现出不良的心脏代谢特征。吸烟率高，以及BMI与不良社会环境的关联，表明慢性病风险因素已经存在，并且可能因药物治疗和社会劣势而加剧。
