Kraus Courtney L, Trivedi Rupal H, Wilson M Edward
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Miles Center for Pediatric Ophthalmology, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina.
J AAPOS. 2015 Apr;19(2):116-8.e1. doi: 10.1016/j.jaapos.2014.11.006. Epub 2015 Mar 26.
To report the intraocular pressure (IOP)-lowering ability and side-effect profile of echothiophate iodide (EI) in the control of glaucoma in aphakic and pseudophakic eyes of children.
The medical records of all aphakic and pseudophakic children treated with EI for IOP lowering after developing glaucoma were retrospectively reviewed.
A total of 32 eyes of 21 children were included. Mean age at cataract removal was 3.9 months (range, 5 days-2.7 years). Mean age of glaucoma diagnosis was 3.2 years (range, 40 days-12 years). Mean duration from cataract removal and diagnosis of glaucoma was 2.9 years (range, 16 days-12 years). EI reduced IOP in 31 of 32 eyes. Mean baseline IOP (29.1 ± 5.3 mm Hg) dropped to 19.6 ± 6.7 mm Hg. Six eyes had IOP spikes that could not be controlled with other medications when commercial unavailability led to discontinuation of EI. Average duration of use was 3.5 years. Mean final IOP on an average of 2.2 medications was 16.9 ± 5.1 mm Hg 7.9 years following initial glaucoma diagnosis. Four eyes required surgery for uncontrolled IOP. Side-effects included transient redness (3/32 eyes), not necessitating discontinuation of EI.
EI lowered IOP to within an acceptable range with no significant adverse events. In several patients it was the only pharmacologic agent that was successful.
报告碘化依可碘酯（EI）在控制儿童无晶状体眼和人工晶状体眼青光眼方面的降眼压能力及副作用情况。
回顾性分析所有因青光眼使用EI降低眼压的无晶状体眼和人工晶状体眼儿童的病历。
共纳入21名儿童的32只眼。白内障摘除时的平均年龄为3.9个月（范围：5天至2.7岁）。青光眼诊断时的平均年龄为3.2岁（范围：40天至12岁）。从白内障摘除到青光眼诊断的平均时长为2.9年（范围：16天至12年）。32只眼中有31只眼的眼压因EI而降低。平均基线眼压（29.1±5.3毫米汞柱）降至19.6±6.7毫米汞柱。当因商业供应问题导致EI停用，6只眼出现用其他药物无法控制的眼压峰值。平均使用时长为3.5年。在初次青光眼诊断7.9年后，平均使用2.2种药物时的平均最终眼压为16.9±5.1毫米汞柱。4只眼因眼压控制不佳需要手术治疗。副作用包括短暂眼红（3/32只眼），无需停用EI。
EI将眼压降至可接受范围内，且无明显不良事件。在一些患者中，它是唯一成功的药物。
