Dikow A, Meschkov T, Radeva M, Pfleiderer G
Folia Haematol Int Mag Klin Morphol Blutforsch. 1985;112(1):38-45.
The present paper deals with a sensitive cytochemical method of identifying alkaline phosphatase (AP) in rosette-forming lymphocytes gained from the peripheral blood of healthy human beings. The percentage of AP-positive lymphocytes amounts to 5%, with all cells comprising B- and O-lymphocyte population and with T-lymphocytes being negative. In a group of healthy test persons, recently, however, having undergone various inflammatory processes or virus diseases, the number of AP-positive lymphocytes is significantly higher, from 41-73% in B- and O-lymphocytes and from 6-38% in T-lymphocytes. This observation indicates that AP in lymphocytes may have a clinical significance in reactive lymphoproliferative processes, which must be elucidated by further investigations.
本文论述了一种灵敏的细胞化学方法，用于鉴定从健康人体外周血中获取的成玫瑰花结淋巴细胞中的碱性磷酸酶（AP）。AP阳性淋巴细胞的百分比为5%，所有细胞包括B淋巴细胞和O淋巴细胞群体，而T淋巴细胞为阴性。然而，最近在一组经历过各种炎症过程或病毒疾病的健康测试者中，AP阳性淋巴细胞的数量显著更高，B淋巴细胞和O淋巴细胞中为41%-73%，T淋巴细胞中为6%-38%。这一观察结果表明，淋巴细胞中的AP在反应性淋巴细胞增殖过程中可能具有临床意义，这一点必须通过进一步研究加以阐明。
