Kreuter Alexander, van Eijk Tina, Lehmann Percy, Fischer Matthias, Horn Thomas, Assaf Chalid, Schley Gaston, Herbst Rudolf, Kellner Ivonne, Weisbrich Christiane, Hyun Julia, Wieland Ulrike, Schlaak Max, Rübben Albert, Lommel Kerstin
Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Germany.
J Dtsch Dermatol Ges. 2015 Apr;13(4):308-15. doi: 10.1111/ddg.12583.
Once classic treatments such as chemotherapy or radiation therapy have been exhausted, only few therapeutic options remain for extensive skin tumors or cutaneous metastases. In such cases, electrochemotherapy may be considered as alternative therapy.
In this retrospective study, clinical features, treatment response, and adverse effects were evaluated in 56 patients treated with electrochemotherapy at six German dermatology departments.
The mean age of the patient cohort (14 men, 42 women) was 69.3 years. Included were 20 patients with skin metastasis of advanced malignant melanoma, 13 patients with breast cancer metastases, 15 patients with primary squamous cell carcinoma of the skin or cutaneous metastases of other carcinoma types, and 8 patients with cutaneous lymphoma or sarcoma. The overall response rate was 44.6% (10.7% complete response; 33.9% partial response). By contrast, 31 (55.4%) patients did not respond (12.5% had stable disease; 42.9%, tumor progression). Patients with melanoma and cutaneous lymphoma or sarcoma responded significantly better than those with carcinoma. Roughly one quarter of patients showed an improvement in tumor-related exudation, fetor, and chronic bleeding.
Showing only few adverse effects, electrochemotherapy was effective in about one half of the patients with advanced tumors. Treatment response appears to depend on the tumor entity.
一旦诸如化疗或放疗等传统治疗手段用尽，对于广泛的皮肤肿瘤或皮肤转移瘤而言，可供选择的治疗方案就寥寥无几了。在这种情况下，电化学疗法可被视为一种替代疗法。
在这项回顾性研究中，对德国六个皮肤科科室接受电化学疗法治疗的56例患者的临床特征、治疗反应及不良反应进行了评估。
患者队列（14名男性，42名女性）的平均年龄为69.3岁。其中包括20例晚期恶性黑色素瘤皮肤转移患者、13例乳腺癌转移患者、15例皮肤原发性鳞状细胞癌或其他癌型皮肤转移患者以及8例皮肤淋巴瘤或肉瘤患者。总体缓解率为44.6%（完全缓解率为10.7%；部分缓解率为33.9%）。相比之下，31例（55.4%）患者无反应（疾病稳定率为12.5%；肿瘤进展率为42.9%）。黑色素瘤、皮肤淋巴瘤或肉瘤患者的反应明显优于癌患者。约四分之一的患者在肿瘤相关渗出、恶臭和慢性出血方面有所改善。
电化学疗法不良反应较少，对约一半的晚期肿瘤患者有效。治疗反应似乎取决于肿瘤类型。
