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从出芽酵母的角度看衰老：我的形态状况

A budding yeast's perspective on aging: the shape I'm in.

作者信息

Smith Jessica, Wright Jill, Schneider Brandt L

机构信息

Department of Medical Education and Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Department of Medical Education and Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

出版信息

Exp Biol Med (Maywood). 2015 Jun;240(6):701-10. doi: 10.1177/1535370215577584. Epub 2015 Mar 27.

DOI:10.1177/1535370215577584
PMID:25819684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4935213/
Abstract

Aging is exemplified by progressive, deleterious changes that increase the probability of death. However, while the effects of age are easy to recognize, identification of the processes involved has proved to be much more difficult. Somewhat surprisingly, research using the budding yeast has had a profound impact on our current understanding of the mechanisms involved in aging. Herein, we examine the biological significance and implications surrounding the observation that genetic pathways involved in the modulation of aging and the determination of lifespan in yeast are highly complicated and conserved.

摘要

衰老表现为渐进性的有害变化，这些变化增加了死亡的可能性。然而，虽然年龄的影响很容易识别，但要确定其中涉及的过程却困难得多。有点令人惊讶的是，利用芽殖酵母进行的研究对我们目前对衰老相关机制的理解产生了深远影响。在此，我们探讨围绕以下观察结果的生物学意义及影响：参与调节酵母衰老和确定寿命的遗传途径非常复杂且保守。

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本文引用的文献

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Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.布洛芬可延长寿命，这在多个物种中都有体现，在酵母中是通过抑制色氨酸的导入来实现的。
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Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging.线粒体应激信号在长寿中的作用：线粒体功能在衰老中的新角色。
Redox Biol. 2014 Jul 27;2:936-44. doi: 10.1016/j.redox.2014.07.005. eCollection 2014.
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The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.SAGA组蛋白去泛素化酶模块通过与Sir2相互作用控制酵母的复制寿命。
Cell Rep. 2014 Jul 24;8(2):477-86. doi: 10.1016/j.celrep.2014.06.037. Epub 2014 Jul 18.
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Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.酵母Isw2染色质重塑酶的失活通过诱导基因毒性应激反应模拟了卡路里限制的长寿效应。
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8
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10
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