Smith Jessica, Wright Jill, Schneider Brandt L
Department of Medical Education and Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Department of Medical Education and Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Exp Biol Med (Maywood). 2015 Jun;240(6):701-10. doi: 10.1177/1535370215577584. Epub 2015 Mar 27.
Aging is exemplified by progressive, deleterious changes that increase the probability of death. However, while the effects of age are easy to recognize, identification of the processes involved has proved to be much more difficult. Somewhat surprisingly, research using the budding yeast has had a profound impact on our current understanding of the mechanisms involved in aging. Herein, we examine the biological significance and implications surrounding the observation that genetic pathways involved in the modulation of aging and the determination of lifespan in yeast are highly complicated and conserved.
衰老表现为渐进性的有害变化，这些变化增加了死亡的可能性。然而，虽然年龄的影响很容易识别，但要确定其中涉及的过程却困难得多。有点令人惊讶的是，利用芽殖酵母进行的研究对我们目前对衰老相关机制的理解产生了深远影响。在此，我们探讨围绕以下观察结果的生物学意义及影响：参与调节酵母衰老和确定寿命的遗传途径非常复杂且保守。
