McLean David L, Dougherty Kimberly J
Department of Neurobiology, Northwestern University, Evanston, IL, USA.
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Curr Opin Neurobiol. 2015 Aug;33:63-70. doi: 10.1016/j.conb.2015.03.001. Epub 2015 Mar 25.
Vertebrate locomotion is executed by networks of neurons within the spinal cord. Here, we describe recent advances in our understanding of spinal locomotor control provided by work using optical and genetic approaches in mice and zebrafish. In particular, we highlight common observations that demonstrate simplification of limb and axial motor pool coordination by spinal network modularity, differences in the deployment of spinal modules at increasing speeds of locomotion, and functional hierarchies in the regulation of locomotor rhythm and pattern. We also discuss the promise of intersectional genetic strategies for better resolution of network components and connectivity, which should help us continue to close the gap between theory and function.
脊椎动物的运动由脊髓内的神经元网络执行。在此，我们描述了利用光学和遗传学方法对小鼠和斑马鱼进行研究后，在理解脊髓运动控制方面取得的最新进展。特别是，我们强调了一些常见的观察结果，这些结果表明脊髓网络模块化简化了肢体和轴向运动神经元池的协调，在运动速度增加时脊髓模块的部署存在差异，以及在运动节律和模式调节中的功能层次结构。我们还讨论了交叉遗传策略在更好地解析网络组件和连接性方面的前景，这将有助于我们继续缩小理论与功能之间的差距。
