Brewster F E, Byron K S, Sullivan J L
J Infect Dis. 1985 Jun;151(6):1109-15. doi: 10.1093/infdis/151.6.1109.
Immunoregulation during acute infection with Epstein-Barr virus (EBV) is incompletely understood, although species of interferon (IFN) may be important immunoregulatory molecules. IFN, 2',5'-oligoadenylate (2',5'-A) synthetase (an IFN-induced enzyme), T and natural killer cell subsets, and natural and anomalous killer cell functions were studied systemically during acute infectious mononucleosis. Serum IFN was not detected (less than 1 international unit/ml) during infection. 2',5'-A synthetase activity was significantly increased in the acute phase of infection when compared with convalescence (34.5 +/- 6.5 vs. 3.6 +/- 1.2 nmol ATP/mg of protein per hr; P less than .01 by Student's t test). A generalized IFN effect was suggested by elevated 2',5'-A synthetase activity in purified neutrophil preparations. Sequential studies revealed a correlation between peak elevations of 2',5'-A synthetase activity and increased percentages of cytotoxic/suppressor cells as well as anomalous killer cell activity against an EBV-infected B cell line. Thus IFN may act as an immunoregulatory lymphokine early in the course of acute EBV infection.
尽管干扰素（IFN）可能是重要的免疫调节分子，但对爱泼斯坦-巴尔病毒（EBV）急性感染期间的免疫调节仍未完全了解。在急性传染性单核细胞增多症期间，对IFN、2',5'-寡腺苷酸（2',5'-A）合成酶（一种IFN诱导酶）、T细胞和自然杀伤细胞亚群以及自然杀伤细胞和异常杀伤细胞功能进行了系统研究。感染期间未检测到血清IFN（低于1国际单位/毫升）。与恢复期相比，感染急性期2',5'-A合成酶活性显著增加（34.5±6.5对3.6±1.2纳摩尔ATP/毫克蛋白质/小时；学生t检验P<0.01）。纯化中性粒细胞制剂中2',5'-A合成酶活性升高提示存在普遍的IFN效应。连续研究显示，2',5'-A合成酶活性的峰值升高与细胞毒性/抑制细胞百分比增加以及针对EBV感染B细胞系的异常杀伤细胞活性之间存在相关性。因此，IFN可能在急性EBV感染过程早期作为一种免疫调节性淋巴因子发挥作用。
