人血清对小鼠单克隆抗体与单纯疱疹病毒1型和2型糖蛋白C和D结合的竞争性抑制作用。
Competitive inhibition by human sera of mouse monoclonal antibody binding to glycoproteins C and D of herpes simplex virus types 1 and 2.
作者信息
Ross C, Glorioso J, Sacks S, Lavery C, Rawls W E
出版信息
J Virol. 1985 Jun;54(3):851-5. doi: 10.1128/JVI.54.3.851-855.1985.
Abstract
A competitive enzyme-linked immunosorbent assay was used to test for human antibodies to antigenic sites on herpes simplex virus (HSV) glycoproteins C and D, which are recognized by mouse monoclonal antibodies. Antibodies capable of blocking the monoclonal antibodies were detected in the human sera, and the inhibition of binding correlated with the histories of herpetic infections. The binding of monoclonal antibody to glycoprotein C of HSV type 2 was inhibited primarily by sera from patients with recurrent herpes genitalis; however, the binding of the monoclonal antibodies to gC of HSV type 1 was inhibited by sera from patients previously infected with either HSV type 1 or HSV type 2. The observations suggest that the antigenic sites defined by the mouse monoclonal antibodies are recognized by the human host.
摘要
采用竞争性酶联免疫吸附试验检测人血清中针对单纯疱疹病毒（HSV）糖蛋白C和D抗原位点的抗体，这些抗原位点可被小鼠单克隆抗体识别。在人血清中检测到了能够阻断单克隆抗体的抗体，且结合抑制作用与疱疹感染史相关。单纯疱疹病毒2型糖蛋白C与单克隆抗体的结合主要被复发性生殖器疱疹患者的血清所抑制；然而，单纯疱疹病毒1型或2型既往感染者的血清均可抑制单克隆抗体与单纯疱疹病毒1型gC的结合。这些观察结果表明，小鼠单克隆抗体所定义的抗原位点可被人类宿主识别。
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