Rawls W E, Wong C L, Blajchman M, Venturelli J, Watts J, Chernesky M, Saigal S
Clin Invest Med. 1984;7(1):13-9.
A prospective study of premature infants admitted to an intensive care neonatal unit was undertaken to evaluate the relative role of blood transfusions and maternal exposure in infections caused by cytomegalovirus (CMV), varicella zoster virus (VZV) and herpes simplex virus (HSV). During the first year of life, 13.7%, 4.8% and 4% of the infants became infected with CMV, VZV and HSV, respectively, as determined by virus isolation or seroconversion. Transfusion in the newborn period did not influence the rates of VZV or HSV infections. A higher rate of CMV infections occurred in transfused (18.8%) than in non-transfused (11%) infants but the difference was not statistically significant. A significant correlation was found between maternal antibody titers and the rate of CMV infection in infants whether or not transfusion occurred. An even stronger association was found between breast feeding and CMV infections. The risk of alloimmunization to erythrocyte and leucocyte antigens was also assessed; no evidence of increased alloimmunization to these antigens was associated with transfusion.
对入住新生儿重症监护病房的早产儿进行了一项前瞻性研究，以评估输血和母亲暴露在巨细胞病毒（CMV）、水痘带状疱疹病毒（VZV）和单纯疱疹病毒（HSV）所致感染中的相对作用。在生命的第一年，通过病毒分离或血清转化确定，分别有13.7%、4.8%和4%的婴儿感染了CMV、VZV和HSV。新生儿期输血不影响VZV或HSV感染率。输血婴儿（18.8%）的CMV感染率高于未输血婴儿（11%），但差异无统计学意义。无论是否输血，均发现母亲抗体滴度与婴儿CMV感染率之间存在显著相关性。母乳喂养与CMV感染之间的关联更强。还评估了对红细胞和白细胞抗原的同种免疫风险；没有证据表明输血会增加对这些抗原的同种免疫。
