Herzog Andrew G, Fowler Kristen M, Sperling Michael R, Massaro Joseph M
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, U.S.A.
Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
Epilepsia. 2015 May;56(5):e58-62. doi: 10.1111/epi.12969. Epub 2015 Mar 30.
The purpose of this study was to determine whether seizure frequency and cycle days with seizure occurrence vary across the menstrual cycle. The subjects were the first 100 women with intractable focal onset seizures, 13-45 years old, who completed the baseline phase of the National Institutes of Health (NIH) Progesterone Trial. Each subject recorded seizures and menses during a 3-month baseline phase. Data consisted of (1) seizure numbers for each cycle day and (2) cycle days with seizure occurrence. Statistical comparisons of seizure frequency and days with seizures were performed using generalized estimating equation one-way analysis of variance (ANOVA) and logistic regression followed by pairwise multiple comparisons of days based on the least square means. Seizure numbers and cycle days with seizure occurrence varied across the menstrual cycle. There was an approximately twofold difference between the highest (day 1) and lowest (day -8) values for both seizure frequency and days with occurrence. The demonstration of variation in seizure frequency and cycle days with seizure occurrence across the menstrual cycle, as well as identification of specific days that have substantially higher or lower frequencies than other days, supports the existence of catamenial epilepsy.
本研究的目的是确定癫痫发作频率以及出现癫痫发作的周期天数在整个月经周期中是否存在差异。研究对象为首批100名年龄在13至45岁之间、患有顽固性局灶性发作癫痫且完成了美国国立卫生研究院（NIH）孕酮试验基线阶段的女性。每位受试者在3个月的基线阶段记录癫痫发作情况和月经情况。数据包括（1）每个周期日的癫痫发作次数以及（2）出现癫痫发作的周期天数。使用广义估计方程单向方差分析（ANOVA）和逻辑回归对癫痫发作频率和癫痫发作天数进行统计比较，随后基于最小二乘均值对天数进行两两多重比较。癫痫发作次数和出现癫痫发作的周期天数在整个月经周期中存在差异。癫痫发作频率和发作天数的最高值（第1天）与最低值（第 -8天）之间存在约两倍的差异。癫痫发作频率和出现癫痫发作的周期天数在整个月经周期中的差异表现，以及对癫痫发作频率明显高于或低于其他日子的特定日期的识别，支持了月经性癫痫的存在。
