1 University of Sydney, Camperdown, New South Wales, Australia.
2 Westmead Millennium Institute, Australia.
J Atten Disord. 2018 Jul;22(9):815-826. doi: 10.1177/1087054715578270. Epub 2015 Mar 30.
Despite advances in our understanding of ADHD as a neurodevelopmental disorder, robust biomarkers are yet to be established in clinical practice. More than 40 years of electroencephalography (EEG)-based research has culminated in the recent Food and Drug Administration (FDA) approval of the theta/beta (EEG power) ratio (TBR) as a diagnostic marker of ADHD.
This review article focuses on resting-state EEG power research in ADHD.
Inconsistent findings in the literature and suggestions of reduced specificity threaten the utility of TBR as a biomarker of ADHD. The use of fixed EEG bands may be a significant limitation, particularly in youth, and alternative approaches are needed.
We propose that a personalized theta-to-alpha cut point or "transition frequency" is a better frame of reference for the measurement of TBR. Such an approach is better placed to test maturational lag and cortical hypoarousal models of ADHD and may in turn have greater utility in supporting diagnosis.
尽管我们对注意力缺陷多动障碍（ADHD）作为一种神经发育障碍的理解有所进步，但在临床实践中仍未建立强大的生物标志物。超过 40 年的基于脑电图（EEG）的研究最终促成了最近食品和药物管理局（FDA）批准 theta/beta（EEG 功率）比值（TBR）作为 ADHD 的诊断标志物。
本文重点介绍 ADHD 的静息态 EEG 功率研究。
文献中的不一致发现和特异性降低的提示威胁着 TBR 作为 ADHD 生物标志物的效用。使用固定的 EEG 波段可能是一个重大限制，尤其是在年轻人中，需要替代方法。
我们提出，个性化的 theta 到 alpha 切点或“过渡频率”是衡量 TBR 的更好参考框架。这种方法更适合测试 ADHD 的成熟滞后和皮质兴奋性降低模型，反过来也可能更有助于支持诊断。
