Li Shengxu, Zhao Jinying, Wang Guangdi, Zhu Yun, Rabito Felicia, Krousel-Wood Marie, Chen Wei, Whelton Paul K
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
Int J Hyg Environ Health. 2015 Jun;218(4):401-6. doi: 10.1016/j.ijheh.2015.03.004. Epub 2015 Mar 14.
Humans are extensively exposed to triclosan, an antibacterial and antifungal agent. Triclosan's effects on human health, however, have not been carefully investigated.
To examine whether triclosan exposure is associated with obesity traits.
This study included 2898 children (6-19 years old) and 5066 adults (20 years or older) who participated in the National Health and Nutrition Examination Surveys (NHANES) 2003-2010 and had a detectable level of urinary triclosan. Multiple linear regression models were used to examine the association between urinary triclosan and both body mass index (BMI) and waist circumference.
Each standard deviation increase in urinary triclosan was associated with a 0.34 (95% confidence interval, CI: 0.05, 0.64) kg/m² lower level of BMI (P=0.02) and 0.92 (95% CI: 0.09, 1.74)cm smaller waist circumference (P=0.03) in boys, and a 0.62 (95% CI: 0.31, 0.94) kg/m² lower level of BMI (P=0.0002) and 1.32 (95% CI: 0.54, 2.09) cm smaller waist circumference in girls (P=0.001); a 0.42 (95% CI: 0.06, 0.77) kg/m² lower level of BMI (P=0.02) and 1.35 (95% CI: 0.48, 2.22) cm smaller waist circumference (P=0.003) in men, and a 0.71 (95% CI: 0.34, 1.07) kg/m² lower level of BMI (P=0.0002) and 1.68 (95% CI: 0.86, 2.50) cm smaller waist circumference (P=0.0001) in women. In both children and adults, there was a consistent trend for lower levels of BMI and smaller waist circumference with increasing levels of urinary triclosan, from the lowest to the highest quartile of urinary triclosan (P ≤ 0.001 in all cases).
Triclosan exposure is inversely associated with BMI and waist circumference. The biological mechanisms linking triclosan exposure to obesity await further investigation.
人类广泛接触三氯生，一种抗菌和抗真菌剂。然而，三氯生对人类健康的影响尚未得到仔细研究。
研究三氯生暴露是否与肥胖特征相关。
本研究纳入了2898名儿童（6 - 19岁）和5066名成年人（20岁及以上），他们参加了2003 - 2010年的国家健康和营养检查调查（NHANES），且尿中三氯生水平可检测。采用多元线性回归模型研究尿中三氯生与体重指数（BMI）和腰围之间的关联。
尿中三氯生每增加一个标准差，男孩的BMI水平降低0.34（95%置信区间，CI：0.05，0.64）kg/m²（P = 0.02），腰围减小0.92（95%CI：0.09，1.74）cm（P = 0.03）；女孩的BMI水平降低0.62（95%CI：0.31，0.94）kg/m²（P = 0.0002），腰围减小1.32（95%CI：0.54，2.09）cm（P = 0.001）；男性的BMI水平降低0.42（95%CI：0.06，0.77）kg/m²（P = 0.02），腰围减小1.35（95%CI：0.48，2.22）cm（P = 0.003）；女性的BMI水平降低0.71（95%CI：0.34，1.07）kg/m²（P = 0.0002），腰围减小1.68（95%CI：0.86，2.50）cm（P = 0.0001）。在儿童和成年人中，随着尿中三氯生水平从最低四分位数增加到最高四分位数，BMI水平降低和腰围减小的趋势一致（所有情况P≤ = 0.001）。
三氯生暴露与BMI和腰围呈负相关。三氯生暴露与肥胖之间的生物学机制有待进一步研究。
