Barnetová L, Martínková J, Stránská V, Nováková A, Faltová V, Malecková M, Odrázková E, Grätz R, Fajmanová M, Martínková J
Cesk Gynekol. 1989 Sep;54(8):561-74.
The authors submit the results of an epidemiological perspective investigation concerned with drug prescription in 372 pregnant women during the period 1983-1988 in two municipal health communities of a regional town with an industrial and agricultural agglomeration. They record for orientation also some other factors which may have an impact on mother and foetus, i.e. smoking, alcohol intake, black coffee. In drugs with a possible negative effect on mother and foetus the prescribed dose was expressed in % DDD and the time interval during pregnancy. The results revealed a significant drop of drug prescription in all groups of drugs, in particular Ferronat, antihistaminic drugs and Diazepam. Perinatal complications, functional or somatic disorders in neonates were manifested in 31% of the total number of neonates. In the small group investigated by the authors neither the effect of the number of drugs nor a relationship between different drugs and certain functional or somatic disorders of the child during delivery were apparent.
作者提交了一项流行病学前瞻性调查的结果，该调查涉及1983年至1988年期间，在一个工农聚集的区域城镇的两个市政卫生社区中，372名孕妇的药物处方情况。他们还记录了一些其他可能对母亲和胎儿有影响的因素，即吸烟、饮酒、饮用黑咖啡。对于可能对母亲和胎儿有负面影响的药物，规定剂量以每日限定剂量的百分比表示，并记录孕期的时间间隔。结果显示，所有药物组的药物处方量都显著下降，尤其是铁制剂、抗组胺药和地西泮。围产期并发症、新生儿的功能或躯体障碍在新生儿总数的31%中有所体现。在作者调查的小组中，药物数量的影响以及不同药物与分娩时儿童某些功能或躯体障碍之间的关系均不明显。
