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为避免交配失误,酵母会集中注意力并进行交流。

To avoid a mating mishap, yeast focus and communicate.

作者信息

McClure Allison W, Lew Daniel J

机构信息

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710

出版信息

J Cell Biol. 2015 Mar 30;208(7):867-8. doi: 10.1083/jcb.201502095.

DOI:10.1083/jcb.201502095
PMID:25825514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4384736/
Abstract

During mating, yeast cells must perforate their rigid cell walls at the right place to allow cell-cell fusion. In this issue, Dudin et al. (2015; J. Cell Biol. http://dx.doi.org/jcb.201411124) image mating fission yeast cells with unprecedented spatiotemporal resolution. The authors find that when mating cells come into contact, they form aster-like actin structures that direct cell wall remodeling precisely to the point of contact.

摘要

在交配过程中,酵母细胞必须在正确的位置穿透其坚硬的细胞壁,以实现细胞间融合。在本期杂志中,杜丁等人(2015年;《细胞生物学杂志》,http://dx.doi.org/jcb.201411124)以前所未有的时空分辨率对交配的裂殖酵母细胞进行成像。作者发现,当交配细胞接触时,它们会形成星状肌动蛋白结构,将细胞壁重塑精确地引导到接触点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bdf/4384736/dfbabee88928/JCB_201502095_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bdf/4384736/dfbabee88928/JCB_201502095_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bdf/4384736/dfbabee88928/JCB_201502095_Fig1.jpg

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本文引用的文献

1
A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.一种formin成核的肌动蛋白星状体聚集细胞壁水解酶以促进裂殖酵母中的细胞融合。
J Cell Biol. 2015 Mar 30;208(7):897-911. doi: 10.1083/jcb.201411124.
2
A model for cell wall dissolution in mating yeast cells: polarized secretion and restricted diffusion of cell wall remodeling enzymes induces local dissolution.交配酵母细胞中细胞壁溶解的模型:细胞壁重塑酶的极化分泌和受限扩散诱导局部溶解。
PLoS One. 2014 Oct 16;9(10):e109780. doi: 10.1371/journal.pone.0109780. eCollection 2014.
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Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
酿酒酵母细胞壁生物发生的调控:细胞壁完整性信号通路。
Genetics. 2011 Dec;189(4):1145-75. doi: 10.1534/genetics.111.128264.
4
The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response.V 类肌球蛋白 Myo2p 在酵母交配反应期间对 Fus2p 运输和肌动蛋白极化是必需的。
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Cell wall construction in Saccharomyces cerevisiae.酿酒酵母中的细胞壁构建
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J Cell Biol. 1996 Dec;135(6 Pt 2):1727-39. doi: 10.1083/jcb.135.6.1727.
8
Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway.细胞核汇聚与膜融合:酵母核配途径中的两个不同事件。
J Cell Biol. 1994 Aug;126(4):911-23. doi: 10.1083/jcb.126.4.911.