Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
J Cell Biol. 2018 May 7;217(5):1559-1561. doi: 10.1083/jcb.201803079. Epub 2018 Apr 11.
All cells show size homeostasis owing to coordination of division with growth. In this issue, Allard et al. (2018. https://doi.org/10.1083/jcb.201709171) establish that transient inhibitory visits of a negative regulator of Cdk1 to cortical oligomeric platforms increase in number and duration with cell growth, suggesting how Cdk1 activation is coupled to cell size.
所有细胞都通过协调分裂和生长来维持自身大小。在本期中，Allard 等人（2018. https://doi.org/10.1083/jcb.201709171）发现，一种细胞周期蛋白依赖性激酶 1（Cdk1）负调控因子短暂抑制性地访问皮质寡聚平台的次数和时间会随着细胞生长而增加，这表明 Cdk1 的激活是如何与细胞大小相耦联的。
