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Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.使用 CRISPR-Cas9 介导的人类肠道类器官工程技术构建结直肠癌模型。
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类器官模型在癌症精准医疗中的应用。

Organoid modeling for cancer precision medicine.

机构信息

Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305 USA.

出版信息

Genome Med. 2015 Mar 31;7(1):32. doi: 10.1186/s13073-015-0158-y. eCollection 2015.

DOI:10.1186/s13073-015-0158-y
PMID:25825593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4377844/
Abstract

Three-dimensional organotypic culture models show great promise as a tool for cancer precision medicine, with potential applications for oncogene modeling, gene discovery and chemosensitivity studies.

摘要

三维器官型培养模型作为癌症精准医疗的工具具有很大的潜力,可应用于癌基因建模、基因发现和化疗敏感性研究。