Singh D, Mattoo S K, Grover S, Kohli A
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
East Asian Arch Psychiatry. 2015 Mar;25(1):3-15.
To study neuropsychological function in subjects with obsessive-compulsive disorder (OCD) with and without co-morbid depression in comparison with healthy controls (HC).
The 3 sample groups included subjects with OCD without depression (OCD group, n = 30); subjects with OCD and depression (OCDD group, n = 20); and HC (n = 25). All 3 groups were matched for age, gender, and years of education, and they were assessed on the following: Trail Making Tests A and B, Verbal Fluency Test, PGI Memory Scale, Stroop test, Tower of London Test, Raven's Standard Progressive Matrices, Wisconsin Card Sorting Test, and the Object Alternation Test.
Both OCD and OCDD groups performed more poorly than HC, whereas the OCDD group performed worse than OCD group. Besides, OCD and OCDD groups had significantly poorer performance on tests of attention, memory, executive functions, verbal fluency, and intelligence. The OCDD group performed worse than the OCD group notably on Verbal Fluency Test, PGI memory test, and Object Alternation Test.
On tests of neurocognitive functioning, the performance of the OCDD group was poorer than the OCD group, and both performed poorer than HC, suggesting that OCD is associated with neurocognitive dysfunction and that this is exacerbated in the presence of depression.
研究伴有和不伴有共病抑郁的强迫症（OCD）患者的神经心理功能，并与健康对照者（HC）进行比较。
3个样本组包括无抑郁的强迫症患者（OCD组，n = 30）；伴有抑郁的强迫症患者（OCDD组，n = 20）；以及健康对照者（n = 25）。所有3组在年龄、性别和受教育年限方面进行了匹配，并对以下项目进行了评估：连线测验A和B、语言流畅性测验、PGI记忆量表、斯特鲁普测验、伦敦塔测验、瑞文标准渐进矩阵测验、威斯康星卡片分类测验和物体交替测验。
OCD组和OCDD组的表现均比HC组差，而OCDD组的表现比OCD组更差。此外，OCD组和OCDD组在注意力、记忆、执行功能、语言流畅性和智力测试中的表现明显更差。OCDD组在语言流畅性测验、PGI记忆测验和物体交替测验中的表现明显比OCD组差。
在神经认知功能测试中，OCDD组的表现比OCD组差，且两组的表现均比HC组差，这表明OCD与神经认知功能障碍有关，且在伴有抑郁时会加剧。
