Diness Jonas G, Bentzen Bo H, Sørensen Ulrik S, Grunnet Morten
*Acesion Pharma, Copenhagen, Denmark; Departments of †Biomedical Science; and ‡Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
J Cardiovasc Pharmacol. 2015 Nov;66(5):441-8. doi: 10.1097/FJC.0000000000000249.
Small-conductance Ca(2+)-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels because they might constitute a relatively atrial-selective target. This review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how antiarrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and it is hoped that this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.
小电导钙激活钾（SK）通道在心脏电生理学领域是相对较新的研究对象。近年来，对这些通道的关注有所增加，因为它们可能构成相对心房选择性的靶点。本综述将首先对SK通道进行一般性介绍，然后阐述其在正常和病理生理条件下在心脏中的假定功能。文中揭示了在心房颤动情况下，通过抑制多种物种的SK通道可获得抗心律失常作用。相反，在心力衰竭情况下抑制SK通道的有益效果存在疑问，仍需研究。近年来对心脏SK通道的认识迅速增加，希望这将阐明抑制SK通道作为一种新的抗心房颤动原理是否具有潜力。
