Liu Xiaomeng, Wang Siping, You Yilin, Meng Minghui, Zheng Zongji, Dong Meng, Lin Jun, Zhao Qianwei, Zhang Chuanhai, Yuan Xiaoxue, Hu Tao, Liu Lieqin, Huang Yuanyuan, Zhang Lei, Wang Dehua, Zhan Jicheng, Jong Lee Hyuek, Speakman John R, Jin Wanzhu
Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
Endocrinology. 2015 Jul;156(7):2461-9. doi: 10.1210/en.2014-1598. Epub 2015 Apr 1.
Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis. In addition, BAT transplantation increased the level of circulating adiponectin, whereas it reduced the levels of circulating free T3 and T4, which regulate thyroid hormone sensitivity in peripheral tissues. BAT transplantation also increased β3-adrenergic receptor and fatty acid oxidation related gene expression in subcutaneous and epididymal (EP) white adipose tissue. Accordingly, BAT transplantation increased whole-body thermogenesis. Taken together our results demonstrate that BAT transplantation may reduce obesity and its related diseases by activating endogenous BAT.
越来越多的证据表明，在饮食诱导肥胖的小鼠模型中，棕色脂肪组织（BAT）移植可增强全身能量代谢。然而，BAT对遗传性肥胖小鼠是否也有这种有益作用仍不清楚。为了解决这个问题，我们将C57/BL6小鼠的BAT移植到年龄和性别匹配的瘦素缺乏的Ob/Ob小鼠的背部皮下区域。有趣的是，BAT移植导致体重增加显著减少，耗氧量增加，全身脂肪量减少，从而改善胰岛素抵抗和肝脂肪变性。此外，BAT移植增加了循环脂联素水平，而降低了循环游离T3和T4水平，这两种激素调节外周组织中的甲状腺激素敏感性。BAT移植还增加了皮下和附睾（EP）白色脂肪组织中β3-肾上腺素能受体和脂肪酸氧化相关基因的表达。因此，BAT移植增加了全身产热。综上所述，我们的结果表明，BAT移植可能通过激活内源性BAT来减轻肥胖及其相关疾病。
