头部激活因子在G2/有丝分裂转变过程中作为NH15-CA2细胞的自分泌生长因子发挥作用。

Schaller H C, Druffel-Augustin S, Dübel S

Zentrum für Molekulare Biologie, Heidelberg, FRG.

EMBO J. 1989 Nov;8(11):3311-8. doi: 10.1002/j.1460-2075.1989.tb08492.x.

The neuropeptide head activator (HA) acts as an autocrine growth factor for the neural cell line NH15-CA2. Cell proliferation is increased in the presence of HA and inhibited by HA peptide-specific antisera. Stimulation of cellular proliferation is visible 2 h after HA application as an increase in cells in mitosis. HA has no direct effect on stimulating DNA synthesis. HA thus functions as a control signal in the G2/mitosis transition and not in the G1/S transition. Receptors for HA are present on small round cells in clusters of foci and not on cells with differentiated morphology, suggesting cell-cycle-dependent HA receptor expression.

神经肽头部激活剂（HA）作为神经细胞系NH15-CA2的自分泌生长因子。在HA存在的情况下细胞增殖增加，而HA肽特异性抗血清则抑制细胞增殖。HA作用2小时后可见细胞增殖受到刺激，表现为有丝分裂细胞数量增加。HA对刺激DNA合成没有直接作用。因此，HA在G2/有丝分裂转变过程中起控制信号的作用，而不是在G1/S转变过程中。HA受体存在于病灶簇中的小圆形细胞上，而不存在于形态已分化的细胞上，这表明HA受体的表达依赖于细胞周期。