Department of Medicine, Division of Pulmonary Critical Care, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina.
J Thorac Oncol. 2015 Jun;10(6):861-71. doi: 10.1097/JTO.0000000000000536.
Lung cancer continues to be a difficult disease frequently diagnosed in late stages with a high mortality and symptom burden. In part because of frequent lung comorbidity, even lung cancer survivors often remain symptomatic and functionally limited. Though targeted therapy continues to increase treatment options for advanced-stage disease, symptom burden remains high with few therapeutic options. In the last several decades, exercise and physical activity have arisen as therapeutic options for obstructive lung disease and lung cancer. To date, exercise has been shown to reduce symptoms, increase exercise tolerance, improve quality of life, and potentially reduce length of stay and postoperative complications. Multiple small trials have been performed in perioperative non-small-cell lung cancer patients, although fewer studies are available for patients with advanced-stage disease. Despite the increased interest in this subject over the last few years, a validated exercise regimen has not been established for perioperative or advanced-stage disease. Clinicians underutilize exercise and pulmonary rehabilitation as a therapy, in part because of the lack of evidence-based consensus as to how and when to implement increasing physical activity. This review summarizes the existing evidence on exercise in lung cancer patients.
肺癌仍然是一种难以治疗的疾病，通常在晚期诊断，死亡率和症状负担高。部分由于肺部合并症频繁，即使是肺癌幸存者也常常存在症状和功能受限。尽管靶向治疗继续增加晚期疾病的治疗选择，但症状负担仍然很高，治疗选择很少。在过去几十年中，运动和身体活动已成为治疗阻塞性肺部疾病和肺癌的选择。迄今为止，运动已被证明可减轻症状，提高运动耐量，改善生活质量，并可能缩短住院时间和减少术后并发症。尽管在过去几年中对这一主题的兴趣有所增加，但尚未为围手术期或晚期疾病建立经过验证的运动方案。临床医生没有充分利用运动和肺康复作为一种治疗方法，部分原因是缺乏循证共识，不知道如何以及何时实施增加身体活动。本综述总结了目前关于肺癌患者运动的研究证据。
