与战斗相关的瓜果腐霉菌侵袭性伤口感染：病例报告及分子诊断效用的讨论
Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics.
作者信息
Farmer Aaron R, Murray Clinton K, Driscoll Ian R, Wickes Brian L, Wiederhold Nathan, Sutton Deanna A, Sanders Carmita, Mende Katrin, Enniss Brent, Feig James, Ganesan Anuradha, Rini Elizabeth A, Vento Todd J
机构信息
San Antonio Military Medical Center, JBSA Fort Sam Houston, Texas, USA
San Antonio Military Medical Center, JBSA Fort Sam Houston, Texas, USA.
出版信息
J Clin Microbiol. 2015 Jun;53(6):1968-75. doi: 10.1128/JCM.00410-15. Epub 2015 Apr 1.
Abstract
We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.
摘要
我们描述了一名22岁的士兵，其全身表面积19%被烧伤，伴有多发伤，伤口感染经序列分析和培养确诊为瓜果腐霉菌感染。生前组织病理学提示播散性腐霉菌感染，包括脑部受累；然而，死后聚合酶链反应（PCR）显示存在雅致小克银汉霉、伞枝犁头霉和瓶梗萨氏霉混合感染。本文讨论了分子诊断在侵袭性真菌感染中的应用。
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本文引用的文献
1
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N Engl J Med. 2014 Jul 10;371(2):150-60. doi: 10.1056/NEJMra1216008.
2
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Surg Infect (Larchmt). 2014 Oct;15(5):521-6. doi: 10.1089/sur.2013.123. Epub 2014 May 12.
3
In vitro susceptibility of zoospores and hyphae of Pythium insidiosum to antifungals.体外检测内脐蠕孢真菌游动孢子和菌丝对各种抗真菌药物的敏感性。
J Antimicrob Chemother. 2014 Jun;69(6):1564-7. doi: 10.1093/jac/dku021. Epub 2014 Feb 11.
4
Necrotizing cutaneous mucormycosis after a tornado in Joplin, Missouri, in 2011.2011 年美国密苏里州乔普林龙卷风后的坏死性皮肤毛霉菌病。
N Engl J Med. 2012 Dec 6;367(23):2214-25. doi: 10.1056/NEJMoa1204781.
5
Invasive mold infections following combat-related injuries.与战斗相关的创伤后的侵袭性霉菌感染。
Clin Infect Dis. 2012 Dec;55(11):1441-9. doi: 10.1093/cid/cis749. Epub 2012 Oct 5.
6
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Vet Microbiol. 2012 May 25;157(1-2):137-42. doi: 10.1016/j.vetmic.2011.12.003. Epub 2011 Dec 9.
7
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8
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9
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J Trauma. 2011 Jul;71(1 Suppl):S62-73. doi: 10.1097/TA.0b013e3182218c99.
10
Infection-associated clinical outcomes in hospitalized medical evacuees after traumatic injury: trauma infectious disease outcome study.创伤后住院医疗后送人员的感染相关临床结局：创伤传染病结局研究
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