Roysommuti Sanya, Kritsongsakchai Angkana, Wyss J Michael
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand,
Adv Exp Med Biol. 2015;803:665-77. doi: 10.1007/978-3-319-15126-7_53.
This study tests the hypothesis that perinatal taurine supplementation alters adult renal function by inhibition of the renin-angiotensin system. Female Sprague-Dawley rats were fed normal rat chow and given water alone (Control) or water containing an angiotensin converting enzyme inhibitor (captopril, 400 mg/ml) from conception until delivery (FD) or from delivery until weaning (LD). After weaning, the rats received normal rat chow and tap water. At 7–8 weeks of age, renal function at rest and after acute saline load was studied in conscious, restrained male rats. Body weight, mean arterial pressure, heart rate, effective renal blood flow, and renal vascular resistance were not significantly different among the three groups. Compared to Control, glomerular filtration rate, but not filtration fraction, significantly increased after saline load in both FD and LD groups. Water excretion significantly increased only in FD compared to Control, while fractional water excretion was significantly increased after saline load in both FD and LD groups. Sodium excretion significantly increased after saline load only in FD, while both captopril-treated groups significantly decreased fractional sodium excretion. Potassium excretion significantly increased in both FD and LD groups, while fractional potassium excretion significantly increased at rest in FD and decreased in LD groups after saline load. These effects of perinatal RAS inhibition on adult renal function contrast sharply, and are opposite in many cases to, the effects of perinatal taurine supplementation. Thus, these data suggest that perinatal taurine supplementation does not alter adult renal function through its ability to inhibit the perinatal RAS.
围产期补充牛磺酸通过抑制肾素 - 血管紧张素系统来改变成年大鼠的肾功能。雌性斯普拉格 - 道利大鼠喂食正常大鼠饲料，从受孕直至分娩期间单独给予水（对照组），或给予含血管紧张素转换酶抑制剂（卡托普利，400毫克/毫升）的水（FD组），或从分娩直至断奶期间给予含血管紧张素转换酶抑制剂的水（LD组）。断奶后，大鼠接受正常大鼠饲料和自来水。在7 - 8周龄时，对清醒、束缚状态下的雄性大鼠研究了静息状态下及急性盐水负荷后的肾功能。三组之间的体重、平均动脉压、心率、有效肾血流量和肾血管阻力无显著差异。与对照组相比，FD组和LD组在盐水负荷后肾小球滤过率显著增加，但滤过分数无显著变化。与对照组相比，仅FD组的水排泄显著增加，而FD组和LD组在盐水负荷后分数水排泄均显著增加。仅FD组在盐水负荷后钠排泄显著增加，而两个卡托普利治疗组的分数钠排泄均显著降低。FD组和LD组的钾排泄均显著增加，而FD组在静息时分数钾排泄显著增加，LD组在盐水负荷后分数钾排泄降低。围产期抑制肾素 - 血管紧张素系统对成年肾功能的这些影响与围产期补充牛磺酸的影响形成鲜明对比，且在许多情况下相反。因此，这些数据表明围产期补充牛磺酸不会通过其抑制围产期肾素 - 血管紧张素系统的能力来改变成年肾功能。
