Güntaş Gülcan, Engin Burhan, Ekmekçi Özlem Balcı, Kutlubay Zekayi, Ekmekci Hakan, Songür Abdullah, Uzunçakmak Tuğba Kevser Üstünbaş, Vehid Hayriye Ertem, Serdaroğlu Server, Tüzün Yalçın, Uzun Hafize
Kırklareli University, School of Health, Kırklareli, İstanbul, Turkey.
Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
Ann Dermatol. 2015 Apr;27(2):178-83. doi: 10.5021/ad.2015.27.2.178. Epub 2015 Mar 24.
Vitiligo is a chronic, common disease of unknown etiology, and oxidative stress is suggested to have a role in its etiopathogenesis.
Advanced oxidation protein products (AOPPs), prooxidant-antioxidant balance (PAB), and ferric-reducing antioxidant power (FRAP) were evaluated regarding their role in the pathogenesis of vitiligo as well as their relationship with clinical presentation and disease severity, and these parameters were compared with those of healthy controls.
The study included 53 patients with vitiligo and 20 healthy volunteers as the control group. AOPP level, PAB, and FRAP were determined by colorimetric methods.
PAB and FRAP level were significantly higher in patients with vitiligo than in healthy controls (p<0.001). The AOPP levels in vitiligo patients were not statistically significantly higher than those in healthy controls. The Vitiligo Area Scoring Index positively correlated with disease duration (rs: 0.531, p<0.001).
To the best of our knowledge, this is the first report of AOPP and PAB status in vitiligo. PAB may be used as an indicator for oxidative stress in the etiopathogenesis of vitiligo. Our results show that these parameters may play a major role in the melanocyte damage observed in vitiligo. Further studies are required to confirm the mechanisms underlying this effect.
白癜风是一种病因不明的慢性常见疾病，氧化应激被认为在其发病机制中起作用。
评估晚期氧化蛋白产物（AOPPs）、促氧化剂 - 抗氧化剂平衡（PAB）和铁还原抗氧化能力（FRAP）在白癜风发病机制中的作用，以及它们与临床表现和疾病严重程度的关系，并将这些参数与健康对照组进行比较。
该研究纳入了53例白癜风患者和20名健康志愿者作为对照组。采用比色法测定AOPP水平、PAB和FRAP。
白癜风患者的PAB和FRAP水平显著高于健康对照组（p<0.001）。白癜风患者的AOPP水平在统计学上并不显著高于健康对照组。白癜风面积评分指数与病程呈正相关（rs：0.531，p<0.001）。
据我们所知，这是关于白癜风中AOPP和PAB状态的首次报告。PAB可作为白癜风发病机制中氧化应激的指标。我们的结果表明，这些参数可能在白癜风中观察到的黑素细胞损伤中起主要作用。需要进一步研究以证实这种作用的潜在机制。
