Department of Respiratory Medicine, Acibadem Medical Faculty, Acibadem University, Istanbul, Turkey.
Department of Medical Biochemistry, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
BMC Pulm Med. 2022 Oct 17;22(1):382. doi: 10.1186/s12890-022-02076-x.
Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Our study was aimed to investigate whether oxidative stress markers can be used as clinical markers in the evaluation of acute PE (APE) severity.
47 patients with objectively documented diagnosis of APE were recorded. Of these patients, 14 had low-risk PE, 16 had moderate-risk PE, and 17 had high-risk PE. 21 healthy subjects were also enrolled in this study. Ischemia-modified albumin (IMA), prooxidants-antioxidants balance (PAB), advanced protein oxidation products (AOPPs), and ferric reducing antioxidant power (FRAP) were measured as oxidative stress parameters to evaluate the role of oxidative stress.
In the low-risk and moderate-risk APE groups, AOPPs and PAB levels were significantly higher and FRAP levels were significantly lower than those in the control group. AOPPs and IMA levels in the patients with high-risk PE were significantly higher than those in both the low-risk and moderate-risk APE patients. There was a significant correlation between levels of AOPPs and the levels of both IMA (r: 0.462, p < 0.001) and PAB (r:0.378, p < 0.005). Serum FRAP levels were negatively correlated with PAB (r:- 0.683, p < 0.001) and AOPPs levels (r:- 0,384, p < 0.001). There was also a significant positive correlation between the serum IMA and PAB levels.
We clearly demonstrated that reactive oxygen species formation is significantly enhanced in APE. IMA and AOPPs may be used as clinical markers in the evaluation of APE severity in clinical practice. However, further studies with larger patient populations and longer follow-up periods are required to confirm the mechanisms underlying these findings.
肺栓塞（PE）是一种常见且可能危及生命的疾病。我们的研究旨在探讨氧化应激标志物是否可用于评估急性 PE（APE）严重程度的临床标志物。
记录了 47 例经客观诊断为 APE 的患者。其中，14 例为低危 PE，16 例为中危 PE，17 例为高危 PE。本研究还纳入了 21 名健康受试者。测定缺血修饰白蛋白（IMA）、促氧化剂-抗氧化剂平衡（PAB）、晚期蛋白氧化产物（AOPPs）和铁还原抗氧化能力（FRAP）作为氧化应激参数，以评估氧化应激的作用。
在低危和中危 APE 组中，AOPPs 和 PAB 水平显著高于对照组，FRAP 水平显著低于对照组。高危 PE 患者的 AOPPs 和 IMA 水平明显高于低危和中危 APE 患者。AOPPs 水平与 IMA（r：0.462，p<0.001）和 PAB（r：0.378，p<0.005）水平呈显著正相关。血清 FRAP 水平与 PAB（r：-0.683，p<0.001）和 AOPPs 水平（r：-0.384，p<0.001）呈负相关。血清 IMA 和 PAB 水平之间也存在显著正相关。
我们明确表明，APE 中活性氧的形成明显增强。IMA 和 AOPPs 可作为临床标志物用于评估 APE 的严重程度。然而，需要进一步的研究来证实这些发现的机制，研究对象为更大的患者群体和更长的随访期。
