Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Clin Exp Dermatol. 2013 Oct;38(7):701-6. doi: 10.1111/ced.12054. Epub 2013 Apr 20.
Vitiligo is an acquired depigmentation disorder, and oxidative stress is suggested to have a major role in its aetiopathogenesis.
To assess whether oxidative stress has a greater role in generalized than in localized vitiligo.
We assessed 31 patients with active vitiligo (17 localized, 14 generalized) and 38 healthy controls. Serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were determined.
Patients with vitiligo had significantly lower TAS and higher TOS and OSI values than controls. Both localized and generalized vitiligo were associated with lower TAS and higher TOS and OSI values, compared with controls, and all three did not differ with vitiligo type.
A systemic oxidative stress exists in patients with vitiligo. These results indicate that the global antioxidant capacity of patients might have been exhausted through a defence mechanism against oxidative processes. The imbalance in TOS/TAS status may have an important role in the aetiopathogenesis of vitiligo, regardless of the clinical variant of the disease.
白癜风是一种获得性色素脱失性疾病，氧化应激被认为在其发病机制中起主要作用。
评估氧化应激在泛发性白癜风中是否比局限性白癜风中起更大的作用。
我们评估了 31 例活动性白癜风患者（17 例局限性，14 例泛发性）和 38 例健康对照者。测定血清总氧化状态（TOS）、总抗氧化状态（TAS）和氧化应激指数（OSI）。
与对照组相比，白癜风患者的 TAS 显著降低，TOS 和 OSI 值显著升高。与对照组相比，局限性和泛发性白癜风患者的 TAS 均降低，TOS 和 OSI 值均升高，且这三种情况均与白癜风类型无关。
白癜风患者存在系统性氧化应激。这些结果表明，患者的全身抗氧化能力可能通过对抗氧化过程的防御机制而耗尽。TOS/TAS 状态的失衡可能在白癜风的发病机制中起重要作用，而与疾病的临床类型无关。
