Hsu Jennifer, Opoka Robert, Lund Troy C
Mayo Medical School, Rochester, Minnesota.
Department of Pediatrics, Makerere University, Kampala, Uganda.
Afr Health Sci. 2015 Mar;15(1):299-301. doi: 10.4314/ahs.v15i1.41.
Patients with hypogammaglobulinemia are susceptible to recurrent bacterial, viral, fungal, and parasitic infections. The most common clinical manifestation includes recurrent severe infections caused by encapsulated bacteria, in which antibody opsonization is the primary defense mechanism. To our knowledge, this is the first case report of hypogammaglobulinemia in a Ugandan child in Sub-Saharan Africa. The case emphasizes the importance of including hypogammaglobulinemia in the differential diagnosis for children presenting with a history of recurrent infections.
To raise the index of clinical suspicion of hypogammaglobulinemia in an African child and allow for prompt recognition and management of hypogammaglobulinemia.
低丙种球蛋白血症患者易反复发生细菌、病毒、真菌和寄生虫感染。最常见的临床表现包括由包膜细菌引起的反复严重感染，其中抗体调理作用是主要的防御机制。据我们所知，这是撒哈拉以南非洲乌干达一名儿童低丙种球蛋白血症的首例病例报告。该病例强调了在有反复感染病史的儿童鉴别诊断中纳入低丙种球蛋白血症的重要性。
提高对非洲儿童低丙种球蛋白血症的临床怀疑指数，并实现对低丙种球蛋白血症的及时识别和管理。
