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利妥昔单抗输注与常见变异型免疫缺陷（CVID）共同作用导致低丙种球蛋白血症的一个有趣病例

An Interesting Case of Hypogammaglobulinemia Caused by the Combined Effect of Rituximab Infusion and Common Variable Immunodeficiency (CVID).

作者信息

Gaba Manish, Jain Dipshi, Kumar Naveen, Pandey Ankita, Dewan Arun

机构信息

Internal Medicine, Max Smart Super Speciality Hospital, New Delhi, IND.

出版信息

Cureus. 2024 Oct 22;16(10):e72108. doi: 10.7759/cureus.72108. eCollection 2024 Oct.

DOI:10.7759/cureus.72108
PMID:39575032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11580101/
Abstract

This case report is about a patient who presented with bilateral fungal pneumonia. He had a background of viral hepatitis-E infection five years ago, non-Hodgkin lymphoma in remission for four years, and a severe COVID-19 infection three years ago. He was found to have a common variable immune deficiency (CVID) in the background of long-standing hypoglobulinemia, which had never been evaluated. The patient had a history of rituximab infusion for the management of non-Hodgkin lymphoma, which likely worsened his hypogammaglobulinemia. This is an interesting case report that discusses hypogammaglobulinemia in the background of CVID and rituximab infusion.

摘要

本病例报告讲述的是一名出现双侧真菌性肺炎的患者。他有五年前戊型肝炎病毒感染史、缓解四年的非霍奇金淋巴瘤病史以及三年前的重症新型冠状病毒肺炎感染史。在长期低球蛋白血症的背景下，他被发现患有常见变异型免疫缺陷（CVID），此前从未对此进行评估。该患者有因非霍奇金淋巴瘤接受利妥昔单抗输注的病史，这可能加重了他的低丙种球蛋白血症。这是一篇有趣的病例报告，讨论了CVID和利妥昔单抗输注背景下的低丙种球蛋白血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/c83ff87b9a82/cureus-0016-00000072108-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/4a117efea4d1/cureus-0016-00000072108-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/373b0a57539c/cureus-0016-00000072108-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/c83ff87b9a82/cureus-0016-00000072108-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/4a117efea4d1/cureus-0016-00000072108-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/373b0a57539c/cureus-0016-00000072108-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfd1/11580101/c83ff87b9a82/cureus-0016-00000072108-i03.jpg

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An Interesting Case of Hypogammaglobulinemia Caused by the Combined Effect of Rituximab Infusion and Common Variable Immunodeficiency (CVID).利妥昔单抗输注与常见变异型免疫缺陷（CVID）共同作用导致低丙种球蛋白血症的一个有趣病例
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本文引用的文献

1
Rituximab Associated Hypogammaglobulinemia in Autoimmune Disease.利妥昔单抗相关的自身免疫性疾病低丙种球蛋白血症。
Front Immunol. 2021 May 12;12:671503. doi: 10.3389/fimmu.2021.671503. eCollection 2021.
2
Hypogammaglobulinemia: a diagnosis that must not be overlooked.低丙种球蛋白血症：一个不容忽视的诊断。
Braz J Med Biol Res. 2019 Oct 10;52(10):e8926. doi: 10.1590/1414-431X20198926. eCollection 2019.
3
Hypogammaglobulinemia in sub-Saharan Africa: a case report and review of the literature.撒哈拉以南非洲地区的低丙种球蛋白血症：一例病例报告及文献综述
Afr Health Sci. 2015 Mar;15(1):299-301. doi: 10.4314/ahs.v15i1.41.
4
Common variable immunodeficiency disorders: division into distinct clinical phenotypes.常见可变免疫缺陷疾病：分为不同的临床表型。
Blood. 2008 Jul 15;112(2):277-86. doi: 10.1182/blood-2007-11-124545. Epub 2008 Mar 4.