心脏再同步治疗：过去、现在与未来
Cardiac resynchronization therapy: past, present, and future.
作者信息
Chatterjee Neal A, Singh Jagmeet P
机构信息
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Harvard Medical School, Cardiology Division, Electrophysiology Laboratory, Cardiac Arrhythmia Service, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
出版信息
Heart Fail Clin. 2015 Apr;11(2):287-303. doi: 10.1016/j.hfc.2014.12.007.
Cardiac resynchronization therapy (CRT), or biventricular pacing, has become a standard therapeutic modality for patients with symptomatic heart failure (HF), depressed left ventricular (LV) function, and electrical dyssynchrony. Despite the overall success of CRT in improving morbidity and mortality in selected patients with HF, a significant minority demonstrates nonresponse. This review describes the electrical and physiologic rationale for biventricular pacing therapy, summarizes landmark clinical trials assessing CRT efficacy, highlights strategies to optimize the response to CRT, and frames future challenges in the use, delivery, and care of patients undergoing CRT.
心脏再同步治疗（CRT），即双心室起搏，已成为有症状心力衰竭（HF）、左心室（LV）功能减退及电不同步患者的标准治疗方式。尽管CRT在改善特定HF患者的发病率和死亡率方面总体取得成功，但仍有相当一部分患者无反应。本综述阐述了双心室起搏治疗的电学和生理学原理，总结了评估CRT疗效的标志性临床试验，强调了优化CRT反应的策略，并阐述了CRT使用、实施及患者护理方面未来面临的挑战。
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