Ekeanyanwu Raphael Chukwuma, Njoku Obioma Uzoma
Department of Biochemistry, Faculty of Medicine, Imo State University Owerri, Imo State, Nigeria.
Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu State, Nigeria.
Chin J Nat Med. 2015 Mar;13(3):183-91. doi: 10.1016/S1875-5364(15)30003-0.
The antidepressant effects of the flavonoid-rich fraction of Monodora tenuifolia seed extract were examined by assessing the extent of attenuation of behavioural alterations and oxidative damage in the rats that were stressed by forced swim test. Compared with the model control group, the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the flavonoid-rich fraction (100 and 200 mg·kg(-1)), comparable to the group treated with the standard drug, fluoxetine (10 mg·kg(-1)). The flavonoid-rich fraction and fluoxetine improved significantly (P < 0.05) the activities of the antioxidant enzymes such as superoxide dismutase and catalase as well as other biochemical parameters such as reduced glutathione, protein, and nitrite in the brain of the stressed rats. These results suggested that the flavonoid-rich fraction of Monodora tenuifolia seed extract exerted the antidepressant-like effects which could be useful in the management of stress induced disease.
通过评估强迫游泳试验应激大鼠行为改变和氧化损伤的减轻程度，研究了薄叶单药花种子提取物富含黄酮部分的抗抑郁作用。与模型对照组相比，富含黄酮部分（100和200 mg·kg(-1)）处理组的行为参数改变显著减轻（P < 0.05），与标准药物氟西汀（10 mg·kg(-1)）处理组相当。富含黄酮部分和氟西汀显著（P < 0.05）提高了应激大鼠大脑中抗氧化酶如超氧化物歧化酶和过氧化氢酶的活性，以及其他生化参数如还原型谷胱甘肽、蛋白质和亚硝酸盐的水平。这些结果表明，薄叶单药花种子提取物富含黄酮部分具有抗抑郁样作用，可能有助于治疗应激诱导的疾病。
