Creeth J E, Kelly S A, Martinez-Mier E A, Hara A T, Bosma M L, Butler A, Lynch R J M, Zero D T
GlaxoSmithKline Consumer Healthcare, Weybridge KT13 0DE, UK.
Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis 46202, USA.
J Dent. 2015 Jul;43(7):823-31. doi: 10.1016/j.jdent.2015.03.008. Epub 2015 Mar 31.
The objective was to evaluate the ability of fluoride in a conventional, non-specialised sodium fluoride-silica dentifrice to promote tooth remineralisation and enamel fluoride uptake (EFU), and assess the resistance of the newly formed mineral to attack by dietary acid, across the concentration range used in mass-market dentifrices.
Subjects wore a palatal appliance containing eight polished bovine enamel specimens, each including an early erosive lesion. In a randomised full-crossover sequence, 62 healthy subjects were treated with dentifrices containing four different fluoride concentrations: no fluoride; 250ppm, 1150ppm and 1426ppm fluoride. At each treatment visit, under supervision, subjects brushed with 1.5g dentifrice and rinsed once while wearing the appliance; the appliance was removed after a 4-h remineralisation period and effects on the enamel specimens determined. The primary efficacy variable was surface microhardness recovery (SMHR); others included EFU, relative erosion resistance (RER) and comparative erosion resistance.
Highly significant linear and, with the exception of SMHR, quadratic dose-response relationships were observed between all efficacy variables and fluoride concentration. For SMHR, EFU and RER, values for the different fluoride concentrations were statistically resolved from one another, with the exception of the two highest fluoride concentrations. The degree of remineralisation and the acid resistance of enamel after treatment were closely related to EFU.
After a single brushing, conventional non-specialised sodium fluoride-silica dentifrices promoted remineralisation of early enamel lesions, and imparted increased acid-resistance to the enamel surface, in a dose-dependent manner at least up to 1500ppm fluoride.
Enamel erosive tissue loss is an increasing concern, associated with modern diets. This study demonstrated that sodium fluoride, in a conventional non-specialised dentifrice formulation, can promote repair of the earliest stages of enamel erosion after a single application, in a dose-dependent fashion across the fluoride concentration range used in mass-market dentifrices. This study is registered in the GlaxoSmithKline Study Register (ID RH01299), available at: www.gsk-clinicalstudyregister.com/study/RH01299.
评估传统的、非专用的含氟牙膏中的氟促进牙齿再矿化和牙釉质氟摄取（EFU）的能力，并评估在大众市场牙膏使用的浓度范围内，新形成的矿物质抵抗膳食酸侵蚀的能力。
受试者佩戴一个含有八个经抛光的牛牙釉质标本的腭部装置，每个标本都包含一个早期侵蚀性病变。按照随机完全交叉顺序，62名健康受试者使用含有四种不同氟浓度的牙膏进行治疗：无氟；250ppm、1150ppm和1426ppm氟。在每次治疗就诊时，在监督下，受试者使用1.5克牙膏刷牙，并在佩戴装置时漱口一次；在4小时的再矿化期后取出装置，并确定对牙釉质标本的影响。主要疗效变量是表面显微硬度恢复（SMHR）；其他变量包括EFU、相对抗侵蚀性（RER）和比较抗侵蚀性。
在所有疗效变量和氟浓度之间观察到高度显著的线性关系，除SMHR外，还有二次剂量反应关系。对于SMHR、EFU和RER，除了两个最高氟浓度外，不同氟浓度的值在统计学上相互区分。治疗后牙釉质的再矿化程度和抗酸性与EFU密切相关。
单次刷牙后，传统的非专用含氟牙膏能促进早期牙釉质病变的再矿化，并以剂量依赖的方式至少在氟浓度达到1500ppm时，使牙釉质表面的抗酸性增加。
牙釉质侵蚀性组织丧失日益受到关注，与现代饮食有关。本研究表明，在传统的非专用牙膏配方中，氟化钠单次应用后能以剂量依赖的方式促进牙釉质侵蚀最早阶段的修复，涵盖大众市场牙膏使用的氟浓度范围。本研究已在葛兰素史克研究注册库（ID RH01299）注册，可在以下网址查询：www.gsk-clinicalstudyregister.com/study/RH01299 。
