GSK Consumer Healthcare, St George's Avenue, Weybridge, Surrey, KT13 0DE, UK.
Syneos Health, Hyderabad, India.
Clin Oral Investig. 2018 Sep;22(7):2543-2552. doi: 10.1007/s00784-018-2351-z. Epub 2018 Feb 8.
The objective of this work was to evaluate effects of a dentifrice containing sodium fluoride (1150 ppm F) and the organic polyphosphate phytate (0.85% w/w of the hexa-sodium salt) on in situ remineralisation of early enamel erosive lesions and resistance to subsequent demineralisation.
Subjects (n = 62) wore palatal appliances holding eight bovine enamel specimens with pre-formed erosive lesions. They brushed their natural teeth with the phytate test dentifrice (TD); a positive control dentifrice (PC, 1150 ppm fluoride as NaF); a reference dentifrice (RD, disodium pyrophosphate + 1100 ppm fluoride as NaF) or a negative control dentifrice (NC, fluoride-free) in a randomised, double-blind, crossover design. Specimens were removed at 2, 4 and 8 h post-brushing and exposed to an ex vivo acid challenge. Surface microhardness (Knoop) was measured at each stage. The primary efficacy variable was relative erosion resistance (RER); other variables included the surface microhardness recovery (SMHR), acid resistance ratio (ARR) and enamel fluoride uptake (EFU).
After 4 h, the results for RER, ARR and EFU were in the order PC > TD = RD > NC with PC > TD = RD = NC for SMHR. Results at 2 and 8 h were generally consistent with the 4 h data. Mineralisation progressed over time. Dentifrices were generally well-tolerated.
In this in situ model, addition of phytate or pyrophosphate to a fluoride dentifrice inhibited the remineralising effect of fluoride. Both formulations still delivered fluoride to the enamel and inhibited demineralisation, albeit to a lesser extent than a polyphosphate-free dentifrice.
Addition of phytate or pyrophosphate to a fluoride dentifrice may reduce its net anti-erosive properties.
本研究旨在评估含氟（1150ppm F）和有机多聚磷酸盐植酸钠（六偏磷酸钠 0.85%w/w）的牙膏对早期釉质侵蚀性病变再矿化和随后脱矿化抵抗力的影响。
62 名受试者佩戴上腭器械，器械上放置 8 个牛牙釉质标本，标本上有预先形成的侵蚀性病变。受试者采用随机、双盲、交叉设计，使用植酸钠牙膏（TD）、阳性对照牙膏（PC，1150ppm 氟化物为 NaF）、参考牙膏（RD，焦磷酸钠+1100ppm 氟化物为 NaF）或阴性对照牙膏（NC，无氟）刷牙。在刷牙后 2、4 和 8 小时取出标本，并进行体外酸挑战。在每个阶段测量表面显微硬度（Knoop）。主要疗效变量是相对侵蚀抵抗力（RER）；其他变量包括表面显微硬度恢复（SMHR）、酸抗性比（ARR）和牙釉质氟摄取量（EFU）。
4 小时后，RER、ARR 和 EFU 的结果顺序为 PC>TD=RD>NC，而 SMHR 的结果为 PC>TD=RD=NC。2 小时和 8 小时的结果通常与 4 小时的数据一致。矿化随着时间的推移而进展。牙膏通常耐受性良好。
在本原位模型中，植酸钠或焦磷酸钠的添加抑制了氟化物的再矿化作用。两种配方仍向牙釉质输送氟化物并抑制脱矿化，尽管效果不及无多聚磷酸盐牙膏。
在氟化物牙膏中添加植酸钠或焦磷酸钠可能会降低其抗侵蚀的净效果。
