一种氟化物漱口液和牙膏在原位龋模型中的随机临床评估。

A randomised clinical evaluation of a fluoride mouthrinse and dentifrice in an in situ caries model.

机构信息

GSK Consumer Healthcare, St George's Avenue, Weybridge, Surrey, KT13 0DE, UK.

Department of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.

出版信息

J Dent. 2018 Mar;70:59-66. doi: 10.1016/j.jdent.2017.12.015. Epub 2017 Dec 28.

DOI:10.1016/j.jdent.2017.12.015

PMID:29289727

Abstract

OBJECTIVES

Fluoride mouthrinses provide advantages for fluoride delivery by maintaining elevated intra-oral fluoride concentrations following fluoride dentifrice use. This in situ caries study investigated potential anti-caries efficacy of a 220 ppm fluoride mouthrinse.

METHODS

This was an analyst-blinded, four-treatment, randomised, crossover study using partially demineralised, gauze-wrapped, human enamel samples mounted in a mandibular partial denture. Participants brushed twice daily for 14 days with either a 1150 ppm fluoride or a fluoride-free placebo dentifrice and either rinsed once daily with the 220 ppm fluoride mouthrinse or not. Following each treatment period, percent surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) were assessed.

RESULTS

Fifty three participants completed the study. Compared with the placebo dentifrice/no rinse treatment, the fluoride-containing regimens demonstrated greater enamel remineralisation (%SMHR) and fluoridation (EFU): fluoride dentifrice/fluoride rinse (%SMHR difference: 21.55 [95% CI: 15.78,27.32]; EFU difference 8.35 [7.21,9.29]); fluoride dentifrice/no rinse: 19.48 [13.81,25.15]; 6.47 [5.35,7.60]; placebo dentifrice/fluoride rinse: 16.76 [11.06,22.45]; 5.87 [4.72,7.00] (all P < .0001). There were no significant differences in%SMHR between fluoride regimens. The fluoride dentifrice/fluoride rinse regimen was associated with higher EFU than the fluoride dentifrice/no rinse (1.88 [0.75,3.01], P = .0013) and placebo dentifrice/fluoride rinse regimens (2.48 [1.34,3.62], P < .0001). Treatments were generally well-tolerated.

CONCLUSIONS

The in situ caries model demonstrated that the fluoride mouthrinse is effective in promoting enamel caries lesion remineralisation and fluoridation whether used following a fluoride or non-fluoride dentifrice. Additive (potential) anti-caries benefits of a fluoride rinse after a fluoride dentifrice were confined to enhancements in lesion fluoridation (EFU).

CLINICAL SIGNIFICANCE

In conjunction with a fluoride dentifrice, fluoride mouthrinses enhance enamel fluoridation, which may be useful in caries prevention.

摘要

目的

氟化物漱口水通过在使用含氟牙膏后保持口腔内氟化物浓度升高，为氟化物输送提供优势。本原位龋研究调查了一种 220ppm 氟化物漱口水的潜在抗龋效果。

方法

这是一项采用部分脱矿、包裹纱布的人釉质样本的分析员盲法、四处理、随机、交叉研究，这些样本被安装在下颌局部义齿上。参与者每天刷牙两次，共 14 天，使用含 1150ppm 氟化物或无氟安慰剂牙膏，并每天使用 220ppm 氟化物漱口水漱口或不漱口。在每个治疗期结束后，评估表面显微硬度恢复百分比（%SMHR）和牙釉质氟摄取量（EFU）。

结果

53 名参与者完成了这项研究。与安慰剂牙膏/无漱口治疗相比，含氟牙膏漱口组显示出更大的牙釉质再矿化（%SMHR）和氟化（EFU）：含氟牙膏/氟化物漱口组（%SMHR 差异：21.55[95%CI：15.78,27.32]；EFU 差异 8.35[7.21,9.29]）；含氟牙膏/无漱口组：19.48[13.81,25.15]；6.47[5.35,7.60]；安慰剂牙膏/氟化物漱口组：16.76[11.06,22.45]；5.87[4.72,7.00]（均 P<0.0001）。在%SMHR 方面，氟化物方案之间没有显著差异。与氟化物牙膏/无漱口方案相比，氟化物牙膏/氟化物漱口方案与更高的 EFU 相关（1.88[0.75,3.01]，P=0.0013）和安慰剂牙膏/氟化物漱口方案（2.48[1.34,3.62]，P<0.0001）。治疗通常耐受性良好。