台湾地区炎症性肠病的趋势：一项基于人群的研究。
The Trend of Inflammatory Bowel Diseases in Taiwan: A Population-Based Study.
作者信息
Kuo Chia-Jung, Yu Kuang-Hui, See Lai-Chu, Chiu Cheng-Tang, Su Ming-Yao, Hsu Chen-Ming, Kuo Chang-Fu, Chiou Meng-Jiun, Liu Jia-Rou, Wang Hung-Wei
机构信息
Department of Gastroenterology and Hepatology, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, 5, Fushin Street, Kweishan, Taoyuan, Taiwan, ROC.
出版信息
Dig Dis Sci. 2015 Aug;60(8):2454-62. doi: 10.1007/s10620-015-3630-z. Epub 2015 Apr 3.
BACKGROUND AND AIM
The purpose of this study was to estimate the sex- and age-specific incidence rates of inflammatory bowel diseases (IBD) in Taiwan. Site-specific cancer occurred in patients with IBD would be reported, too.
METHODS
A retrospective study by analyzing the data from the National Health Insurance Research Database of Taiwan.
RESULTS
Between 2000 and 2010, the overall incidence rate of Crohn's disease (CD) and ulcerative colitis (UC) was 0.208 and 0.838 per 100,000 person-years. For male, the incidence rate of CD was 0.195 (95 % CI 0.113-0.276) per 100,000 persons in 2000 and increased to 0.318 (95 % CI 0.216-0.421) per 100,000 persons in 2010. For female, the incidence rate of CD was 0.092 (95 % CI 0.035-0.149) per 100,000 persons in 2000 and increased to 0.210 (95 % CI 0.128-0.293) per 100,000 persons in 2010. For male, the incidence rate of UC was 0.690 (95 % CI 0.537-0.843) per 100,000 persons in 2000 and increased to 1.351 (95 % CI, 1.140-1.562) per 100,000 persons in 2010. For female, the incidence rate of UC was 0.386 (95 % CI 0.269-0.503) per 100,000 persons in 2000 and increased to 0.858 (95 % CI 0.691-1.024) per 100,000 persons in 2010. Among the CD patients, 0.19 % had colorectal cancers (1/519). Among the UC patients, 0.24 % had colorectal cancers (5/2098).
CONCLUSIONS
This nationwide population-based longitudinal epidemiological study of IBD in Taiwan provides data for future global comparisons.
背景与目的
本研究旨在评估台湾地区炎症性肠病（IBD）的性别及年龄特异性发病率。同时也将报告IBD患者中特定部位癌症的发生情况。
方法
通过分析台湾地区国民健康保险研究数据库的数据进行回顾性研究。
结果
2000年至2010年期间，克罗恩病（CD）和溃疡性结肠炎（UC）的总体发病率分别为每10万人年0.208例和0.838例。男性中，CD的发病率在2000年为每10万人0.195例（95%可信区间0.113 - 0.276），至2010年增至每10万人0.318例（95%可信区间0.216 - 0.421）。女性中，CD的发病率在2000年为每10万人0.092例（95%可信区间0.035 - 0.149），至2010年增至每10万人0.210例（95%可信区间0.128 - 0.293）。男性中，UC的发病率在2000年为每10万人0.690例（95%可信区间0.537 - 0.843），至2010年增至每10万人1.351例（95%可信区间1.140 - 1.562）。女性中，UC的发病率在2000年为每10万人0.386例（95%可信区间0.269 - 0.503），至2010年增至每10万人0.858例（95%可信区间0.691 - 1.024）。在CD患者中，0.19%发生了结直肠癌（1/519）。在UC患者中，0.24%发生了结直肠癌（5/2098）。
结论
这项基于全台湾地区人群的IBD纵向流行病学研究为未来的全球比较提供了数据。
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