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过敏性鼻炎的优化管理。

Optimal management of allergic rhinitis.

作者信息

Scadding Glenis K

出版信息

Arch Dis Child. 2015 Jun;100(6):576-82. doi: 10.1136/archdischild-2014-306300. Epub 2015 Apr 2.

Abstract

Allergic rhinitis (AR), the most common chronic disease in childhood is often ignored, misdiagnosed and/or mistreated. Undertreated AR impairs quality of life, exacerbates asthma and is a major factor in asthma development. It can involve the nose itself, as well as the organs connected with the nose manifesting a variety of symptoms. Evidence-based guidelines for AR therapy improve disease control. Recently, paediatric AR guidelines have been published by the European Academy of Allergy and Clinical Immunology and are available online, as are a patient care pathway for children with AR and asthma from the Royal College of Paediatrics and Child Health. Management involves diagnosis, followed by avoidance of relevant allergens, with additional pharmacotherapy needed for most sufferers. This ranges, according to severity, from saline sprays, through non-sedating antihistamines, oral or topical, with minimally bioavailable intranasal corticosteroids for moderate/severe disease, possibly plus additional antihistamine or antileukotriene. The concept of rhinitis control is emerging, but there is no universally accepted definition. Where pharmacotherapy fails, allergen-specific immunotherapy, which is uniquely able to alter long-term disease outcomes, should be considered. The subcutaneous form (subcutaneous immunotherapy) in children has been underused because of concerns regarding safety and acceptability of injections. Sublingual immunotherapy is both efficacious and safe for grass pollen allergy. Further studies on other allergens in children are needed. Patient, carer and practitioner education into AR and its treatment are a vital part of management.

摘要

变应性鼻炎(AR)是儿童期最常见的慢性疾病,却常常被忽视、误诊和/或治疗不当。治疗不充分的AR会损害生活质量,加重哮喘,且是哮喘发病的主要因素。它可累及鼻本身,以及与鼻相连的器官,表现出多种症状。基于证据的AR治疗指南可改善疾病控制。最近,欧洲变态反应和临床免疫学会已发布儿科AR指南,可在线获取,皇家儿科学会和儿童健康学会也发布了AR和哮喘患儿的患者护理路径。管理包括诊断,随后避免接触相关变应原,大多数患者还需要额外的药物治疗。根据病情严重程度,治疗方法包括盐水喷雾、非镇静性抗组胺药(口服或局部用药),对于中重度疾病,使用生物利用度极低的鼻用糖皮质激素,可能还需加用其他抗组胺药或白三烯调节剂。鼻炎控制的概念正在兴起,但尚无普遍接受的定义。当药物治疗无效时,应考虑变应原特异性免疫疗法,它是唯一能够改变疾病长期转归的方法。由于担心注射的安全性和可接受性,儿童皮下免疫疗法(皮下注射免疫疗法)的应用一直不足。舌下免疫疗法对草花粉过敏既有效又安全。还需要对儿童的其他变应原进行进一步研究。对患者、护理人员和从业者进行AR及其治疗方面的教育是管理的重要组成部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c99c/4514979/243072b5532c/archdischild-2014-306300f01.jpg

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