Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, Ga.
Department of Otolaryngology, University of Central Florida, Orlando, Fla.
J Allergy Clin Immunol Pract. 2023 Mar;11(3):773-796. doi: 10.1016/j.jaip.2023.01.007.
An updated edition of the International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has recently been published. This consensus document, which included the participation of 87 primary authors and 40 additional consultant authors, who critically appraised evidence on 144 individual topics concerning allergic rhinitis, provides guidance for health care providers using the evidence-based review with recommendations (EBRR) methodology. This synopsis highlights topical areas including pathophysiology, epidemiology, disease burden, risk and protective factors, evaluation and diagnosis, aeroallergen avoidance and environmental controls, single and combination pharmacotherapy options, allergen immunotherapy (subcutaneous, sublingual, rush, cluster), pediatric considerations, alternative and emerging therapies, and unmet needs. Based on the EBRR methodology, ICAR:AR includes strong recommendations for the treatment of allergic rhinitis: (1) for the use of newer generation antihistamines compared with first-generation alternatives, intranasal corticosteroid, intranasal saline, combination therapy with intranasal corticosteroid plus intranasal antihistamine for patients not responding to monotherapy, and subcutaneous immunotherapy and sublingual tablet immunotherapy in properly selected patients; (2) against the use of oral decongestant monotherapy and routine use of oral corticosteroids.
最近发布了《过敏和鼻科学国际共识声明:过敏性鼻炎(ICAR:AR)》的更新版。该共识文件由 87 名主要作者和 40 名额外顾问作者参与,他们对 144 个与过敏性鼻炎相关的个别主题的证据进行了严格评估,为使用基于证据的审查和建议(EBRR)方法的医疗保健提供者提供了指导。该摘要重点介绍了包括病理生理学、流行病学、疾病负担、风险和保护因素、评估和诊断、变应原回避和环境控制、单一和联合药物治疗选择、变应原免疫治疗(皮下、舌下、冲击、集群)、儿科注意事项、替代和新兴疗法以及未满足的需求等领域。基于 EBRR 方法,ICAR:AR 对过敏性鼻炎的治疗提出了强烈建议:(1)对于使用新一代抗组胺药而非第一代替代药物、鼻内皮质类固醇、鼻内生理盐水、对于未对单药治疗有反应的患者,联合鼻内皮质类固醇和鼻内抗组胺药治疗,以及在适当选择的患者中皮下免疫治疗和舌下片剂免疫治疗;(2)反对使用口服减充血剂单药治疗和常规使用口服皮质类固醇。