Elbarbary Reyad A, Maquat Lynne E
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA
Genes Dev. 2015 Apr 1;29(7):687-9. doi: 10.1101/gad.261438.115.
A subset of messenger RNAs (mRNAs) that contain inverted Alu elements in their 3' untranslated region are inefficiently exported to the cytoplasm and retained in subnuclear bodies called paraspeckles. The arginine methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1) promotes the nuclear export of these mRNAs by methylating the paraspeckle component p54(nrb), which reduces the binding of p54(nrb) to the inverted Alu elements, and down-regulating synthesis of another paraspeckle component, the long noncoding RNA NEAT1, which inhibits paraspeckle formation.
在其3'非翻译区含有反向Alu元件的信使核糖核酸（mRNA）亚群被低效地转运到细胞质中，并保留在称为副斑点的亚核小体中。精氨酸甲基转移酶CARM1（共激活因子相关精氨酸甲基转移酶1）通过使副斑点成分p54（nrb）甲基化来促进这些mRNA的核输出，这减少了p54（nrb）与反向Alu元件的结合，并下调另一种副斑点成分——长链非编码RNA NEAT1的合成，而NEAT1会抑制副斑点的形成。
