Biswas N R, Garg S K, Kumar N, Mukherjee S, Sharma P L
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Int J Clin Pharmacol Ther Toxicol. 1989 Oct;27(10):515-9.
The pharmacokinetic and pharmacodynamic studies of four different brands of propranolol (Inderal, Ciplar, Corbeta and Propal) were carried out after single and multiple dosing on six normal adult healthy volunteers in a randomized crossover fashion to determine any inter-brand variations in bioavailability and pharmacodynamic effects. No significant difference was observed in any of the pharmacokinetic and pharmacodynamic parameters of four different brands of propranolol studied.
对6名正常成年健康志愿者进行了随机交叉试验，在单次和多次给药后开展了4种不同品牌普萘洛尔（心得安、西普拉、可倍特和普帕）的药代动力学和药效学研究，以确定各品牌间生物利用度和药效学效应的差异。所研究的4种不同品牌普萘洛尔的任何药代动力学和药效学参数均未观察到显著差异。
