National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China ; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Evid Based Complement Alternat Med. 2015;2015:642327. doi: 10.1155/2015/642327. Epub 2015 Mar 16.
Increasing evidence shows that grains may play a role in disease prevention beyond the simple provision of energy and nutrients. It has been reported that some components contained in grains exert their functional effects on viral and bacterial infections and protect against various cancers. However, until now, hardly any intervention studies have investigated the effects of grains or grain based extracts on the inhibition of HIV-1 infection. In this study, the antiviral function of a zymolytic grain based extract (ZGE) was detected in vitro and in rats, and the antiviral mechanism was investigated. Results showed that ZGE had an inhibition effect on HIV-1 infection in vitro with low cytotoxic effects. The study of the mechanism demonstrated that this functional food possibly acted on the viral surface structure protein gp120 which is responsible for cell binding, as well as on the postattachment stage of the virus. The sera of model rats administrated with this food by gavage presented anti-infection abilities against HIV-1 in vitro during a serum concentration associated period of time. These findings provide valuable insights into the application of ZGE on the control of viral load, which may contribute to future anti-HIV treatment with less adverse effects.
越来越多的证据表明，谷物除了提供能量和营养之外，在疾病预防方面可能发挥作用。据报道，谷物中含有的一些成分对病毒和细菌感染发挥了其功能作用，并能预防各种癌症。然而，到目前为止，几乎没有任何干预研究调查谷物或谷物提取物对抑制 HIV-1 感染的影响。在这项研究中，体外和大鼠实验检测了一种酶解谷物提取物（ZGE）的抗病毒功能，并研究了其抗病毒机制。结果表明，ZGE 对体外 HIV-1 感染具有抑制作用，且细胞毒性低。研究表明，这种功能性食品可能作用于负责细胞结合的病毒表面结构蛋白 gp120，以及病毒附着后的阶段。通过灌胃给予这种食物的模型大鼠的血清在一段时间内与血清浓度相关的时期内，在体外表现出抗 HIV-1 的感染能力。这些发现为 ZGE 在控制病毒载量方面的应用提供了有价值的见解，这可能有助于未来开发副作用更小的抗 HIV 治疗方法。
