School of Life Science, Jilin University, Changchun 130012, China.
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130012, China.
Int J Mol Sci. 2019 Jul 16;20(14):3489. doi: 10.3390/ijms20143489.
Many reports have shown that grains play an important role in our daily lives and can provide energy and nutrients to protect us from various diseases, and they are considered to be indispensable parts of our lives. It has been reported that some constituents in grains could exert functional effects against HIV infections and multiple cancers. Zymolytic grain can produce some new useful molecules and thus support the cell nutrients in the human body. In this study, the effects of zymolytic grain extract (ZGE) supernatants on the changes of nematode indicators were investigated, including lifespan, self-brood size, and body length in environmental conditions (temperature, ultraviolet radiation or 5-fluoro-2'-deoxyuridine (FUDR) stimuli). We found that, compared to the control group, the ZGE supernatant-feeding group could prolong the lifespan of nematodes under normal conditions. More importantly, ZGE supernatants could improve the ability of nematodes to resist stress. When the concentration of FUDR was 400 or 50 μM, the ZGE supernatant-feeding group could prolong lifespan by an average of 38.4% compared to the control group, and the eggs of the ZGE supernatant-feeding group could hatch and develop into adults. These results indicated that ZGE could protect from external stress and thus prolong their lifespan and improve the physiological state of nematodes. Therefore, ZGE supernatant has potential to be used as a nutritional product in antioxidant and anti-aging research.
许多报告表明，谷物在我们的日常生活中扮演着重要的角色，它们可以提供能量和营养，保护我们免受各种疾病的侵害，是我们生活中不可或缺的一部分。有报道称，谷物中的某些成分可以发挥抗 HIV 感染和多种癌症的功能作用。发酵谷物可以产生一些新的有用分子，从而支持人体细胞的营养。在这项研究中，研究了发酵谷物提取物（ZGE）上清液对环境条件（温度、紫外线辐射或 5-氟-2'-脱氧尿苷（FUDR）刺激）下线虫指标变化的影响，包括寿命、自繁大小和体长。我们发现，与对照组相比，ZGE 上清液喂养组可以延长线虫在正常条件下的寿命。更重要的是，ZGE 上清液可以提高线虫抵抗应激的能力。当 FUDR 浓度为 400 或 50 μM 时，与对照组相比，ZGE 上清液喂养组的寿命平均延长了 38.4%，ZGE 上清液喂养组的卵可以孵化并发育成成虫。这些结果表明，ZGE 可以保护线虫免受外部压力，从而延长其寿命并改善线虫的生理状态。因此，ZGE 上清液有可能作为抗氧化和抗衰老研究中的营养产品。
